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    TJP2 tight junction protein 2 [ Homo sapiens (human) ]

    Gene ID: 9414, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TJP2provided by HGNC
    Official Full Name
    tight junction protein 2provided by HGNC
    Primary source
    HGNC:HGNC:11828
    See related
    Ensembl:ENSG00000119139 MIM:607709; AllianceGenome:HGNC:11828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZO2; X104; FHCA1; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11
    Summary
    This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in lung (RPKM 15.3), fat (RPKM 14.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TJP2 in Genome Data Viewer
    Location:
    9q21.11
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (69121264..69255208)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (81294639..81423094)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (71736180..71870124)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr9.764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28445 Neighboring gene Sharpr-MPRA regulatory region 187 Neighboring gene Friedreich ataxia repeat instability region Neighboring gene protein kinase cAMP-activated catalytic subunit gamma Neighboring gene Sharpr-MPRA regulatory region 4997 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:71660286-71661281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71669749-71670250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71670251-71670750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71681521-71682120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:71683371-71683870 Neighboring gene frataxin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:71703383-71703883 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71705161-71706130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71731558-71732058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71732059-71732559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71735458-71736416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:71745576-71746105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28446 Neighboring gene uncharacterized LOC124902175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28447 Neighboring gene Sharpr-MPRA regulatory region 4978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71856696-71857196 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:71857197-71857697 Neighboring gene uncharacterized LOC124902176 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:71897736-71898504 Neighboring gene NANOG hESC enhancer GRCh37_chr9:71898508-71899009 Neighboring gene Sharpr-MPRA regulatory region 15637 Neighboring gene BRAF-activated non-protein coding RNA Neighboring gene endosomal transmembrane epsin interactor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma. Chlenski A, et al. Int J Cancer, 1999 Jul 2. PMID 10360833
    2. Long non-coding RNA AB209630 suppresses cell proliferation and metastasis in human hepatocellular carcinoma. Li T, et al. Exp Ther Med, 2017 Oct. PMID 29042928, Free PMC Article
    3. Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues. Chlenski A, et al. Biochim Biophys Acta, 2000 Oct 2. PMID 11018256
    4. ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation. González-Mariscal L, et al. Ann N Y Acad Sci, 2017 Jun. PMID 28415133
    5. Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2. Glaunsinger BA, et al. EMBO J, 2001 Oct 15. PMID 11598001, Free PMC Article

    See all (189) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
      Title: p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
    2. Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
      Title: Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
    3. TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
      Title: TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
    4. New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
      Title: New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
    5. Supra-molecular assembly and positioning of tight junctions as continuous networks of adhesion strands are dependent on the membrane-associated scaffolding proteins ZO1 and ZO2.
      Title: Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
    6. It is a potential target of miR-543.
      Title: miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A.
    7. Results suggested that a reduction in CLDN18-dependent ZO-2 expression enhances MMP2 expression in lung adenocarcinoma cells, resulting in the promotion of the cell migration.
      Title: ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.
    8. Mutations in the genes responsible for PFIC may be involved in both young and adults with cryptogenic cholestasis in a considerable number of cases, including in heterozygous status.
      Title: Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing.
    9. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS
      Title: Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
    10. A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39
      Title: Genetic profiling of children with advanced cholestatic liver disease.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Cholestasis, progressive familial intrahepatic, 4
    MedGen: C2931067 OMIM: 615878 GeneReviews: Not available
    		Compare labs
    Hypercholanemia, familial 1
    MedGen: C5542604 OMIM: 607748 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
    EBI GWAS Catalog
    Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of cultured human brain endothelial cells with HIV-1 gp120 results in increased permeability of the endothelial monolayer and causes disruption and downregulation of the tight junction proteins ZO-1, ZO-2, and occludin in these cells PubMed
    Tat tat Exposure of brain micro vascular endothelial cells to HIV-1 Tat results in a decrease of claudin-1, claudin-5, and zonula occludens-2 expression and cellular redistribution of claudin-5, suggesting potential disturbance of the blood-brain barrier by Tat PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26306

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of endothelial intestinal barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of endothelial intestinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of blood-brain barrier permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    tight junction protein ZO-2
    Names
    Friedreich ataxia region gene X104 (tight junction protein ZO-2)
    zona occludens 2
    zonula occludens protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016342.2 RefSeqGene

      Range
      78371..159302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1201

    mRNA and Protein(s)

    1. NM_001170414.2 → NP_001163885.1  tight junction protein ZO-2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences include a distinct 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AA724570, AI738923, AK295016, CX865985, DA270962, DB196171
      UniProtKB/TrEMBL
      B7Z2R3
      Related
      ENSP00000496877.1, ENST00000647986.1
      Conserved Domains (5) summary
      cd12027
      Location:581 → 643
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:677 → 856
      GuKc; Guanylate kinase homologues
      COG0265
      Location:279 → 369
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. NM_001170415.1 → NP_001163886.1  tight junction protein ZO-2 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences include a distinct 5' UTR and translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK302483, AL358113, DC325189
      Consensus CDS
      CCDS55315.1
      UniProtKB/TrEMBL
      A0A3B3ITE1
      Related
      ENSP00000442090.1, ENST00000535702.6
      Conserved Domains (5) summary
      cd12027
      Location:608 → 670
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:704 → 883
      GuKc; Guanylate kinase homologues
      COG0265
      Location:306 → 396
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:303 → 386
      PDZ; PDZ domain (Also known as DHR or GLGF)

    3. NM_001170416.2 → NP_001163887.1  tight junction protein ZO-2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AL358113
      Consensus CDS
      CCDS55316.1
      UniProtKB/TrEMBL
      A0A3B3ITE1
      Related
      ENSP00000438262.1, ENST00000539225.2
      Conserved Domains (5) summary
      cd12027
      Location:635 → 697
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:731 → 910
      GuKc; Guanylate kinase homologues
      COG0265
      Location:333 → 423
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:63 → 148
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:330 → 413
      PDZ; PDZ domain (Also known as DHR or GLGF)

    4. NM_001369870.1 → NP_001356799.1  tight junction protein ZO-2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL162730, AL358113, AL590238
      UniProtKB/TrEMBL
      A0A3B3ITE1
      Conserved Domains (6) summary
      cd12027
      Location:579 → 641
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:675 → 854
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 251
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    5. NM_001369871.1 → NP_001356800.1  tight junction protein ZO-2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL358113, AL590238
      UniProtKB/TrEMBL
      A0A3B3ITE1
      Conserved Domains (6) summary
      cd12027
      Location:581 → 643
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:677 → 856
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 251
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    6. NM_001369872.1 → NP_001356801.1  tight junction protein ZO-2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL358113
      UniProtKB/TrEMBL
      A0A3B3ISZ5
      Related
      ENSP00000497539.1, ENST00000649943.1
      Conserved Domains (6) summary
      cd12027
      Location:604 → 666
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:700 → 879
      GuKc; Guanylate kinase homologues
      smart00228
      Location:303 → 385
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:183 → 274
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:144 → 226
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    7. NM_001369873.1 → NP_001356802.1  tight junction protein ZO-2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL358113
      UniProtKB/TrEMBL
      B7Z954
      Conserved Domains (6) summary
      cd12027
      Location:604 → 666
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:700 → 879
      GuKc; Guanylate kinase homologues
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:183 → 274
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:144 → 226
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:299 → 382
      PDZ; PDZ domain (Also known as DHR or GLGF)

    8. NM_001369874.1 → NP_001356803.1  tight junction protein ZO-2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL358113
      Consensus CDS
      CCDS94416.1
      UniProtKB/TrEMBL
      A0A3B3IU51, B7Z2R3
      Related
      ENSP00000498068.1, ENST00000649134.1
      Conserved Domains (6) summary
      cd12027
      Location:608 → 670
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:704 → 883
      GuKc; Guanylate kinase homologues
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:187 → 278
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:148 → 230
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:303 → 386
      PDZ; PDZ domain (Also known as DHR or GLGF)

    9. NM_001369875.1 → NP_001356804.1  tight junction protein ZO-2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL358113
      UniProtKB/TrEMBL
      A0A3B3ITE1
      Related
      ENSP00000497861.1, ENST00000650084.1
      Conserved Domains (6) summary
      cd12027
      Location:608 → 670
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:704 → 883
      GuKc; Guanylate kinase homologues
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:187 → 278
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:148 → 230
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:303 → 386
      PDZ; PDZ domain (Also known as DHR or GLGF)

    10. NM_004817.4 → NP_004808.2  tight junction protein ZO-2 isoform 1

      See identical proteins and their annotated locations for NP_004808.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AL358113, BC027592, DB090695, L27476
      Consensus CDS
      CCDS6627.1
      UniProtKB/Swiss-Prot
      A2A3H9, B7Z2R8, B7Z7T6, F5H301, F5H886, Q15883, Q5VXL0, Q5VXL1, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1, Q9UDY2
      UniProtKB/TrEMBL
      A0A3B3ITE1
      Related
      ENSP00000366453.4, ENST00000377245.9
      Conserved Domains (5) summary
      cd12027
      Location:604 → 666
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:700 → 879
      GuKc; Guanylate kinase homologues
      COG0265
      Location:302 → 392
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:299 → 382
      PDZ; PDZ domain (Also known as DHR or GLGF)

    11. NM_201629.3 → NP_963923.1  tight junction protein ZO-2 isoform 2

      See identical proteins and their annotated locations for NP_963923.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant (1). The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA724570, AK295016, AK304447, AL358113, DB090695
      Consensus CDS
      CCDS6628.1
      UniProtKB/TrEMBL
      B7Z2R3
      Related
      ENSP00000345893.4, ENST00000348208.9
      Conserved Domains (5) summary
      cd12027
      Location:604 → 666
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:700 → 879
      GuKc; Guanylate kinase homologues
      COG0265
      Location:302 → 392
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00595
      Location:299 → 382
      PDZ; PDZ domain (Also known as DHR or GLGF)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      69121264..69255208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519206.3 → XP_011517508.1  tight junction protein ZO-2 isoform X1

      See identical proteins and their annotated locations for XP_011517508.1

      UniProtKB/TrEMBL
      A0A3B3ITE1
      Conserved Domains (6) summary
      cd12027
      Location:581 → 643
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:677 → 856
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 251
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    2. XM_011519208.3 → XP_011517510.1  tight junction protein ZO-2 isoform X1

      See identical proteins and their annotated locations for XP_011517510.1

      UniProtKB/TrEMBL
      A0A3B3ITE1
      Conserved Domains (6) summary
      cd12027
      Location:581 → 643
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:677 → 856
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 251
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    3. XM_047424090.1 → XP_047280046.1  tight junction protein ZO-2 isoform X1

    4. XM_047424095.1 → XP_047280051.1  tight junction protein ZO-2 isoform X2

    5. XM_047424091.1 → XP_047280047.1  tight junction protein ZO-2 isoform X1

    6. XM_011519207.3 → XP_011517509.1  tight junction protein ZO-2 isoform X1

      See identical proteins and their annotated locations for XP_011517509.1

      UniProtKB/TrEMBL
      A0A3B3ITE1
      Related
      ENSP00000489860.1, ENST00000636438.1
      Conserved Domains (6) summary
      cd12027
      Location:581 → 643
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:677 → 856
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 251
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    7. XM_047424092.1 → XP_047280048.1  tight junction protein ZO-2 isoform X1

    8. XM_011519209.3 → XP_011517511.1  tight junction protein ZO-2 isoform X1

      See identical proteins and their annotated locations for XP_011517511.1

      UniProtKB/TrEMBL
      A0A3B3ITE1
      Conserved Domains (6) summary
      cd12027
      Location:581 → 643
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:677 → 856
      GuKc; Guanylate kinase homologues
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01622
      Location:160 → 251
      SF-CC1; splicing factor, CC1-like family
      TIGR01642
      Location:121 → 203
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam00595
      Location:276 → 359
      PDZ; PDZ domain (Also known as DHR or GLGF)

    9. XM_047424094.1 → XP_047280050.1  tight junction protein ZO-2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      81294639..81423094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364197.1 → XP_054220172.1  tight junction protein ZO-2 isoform X1

    2. XM_054364195.1 → XP_054220170.1  tight junction protein ZO-2 isoform X1

    3. XM_054364196.1 → XP_054220171.1  tight junction protein ZO-2 isoform X1

    4. XM_054364202.1 → XP_054220177.1  tight junction protein ZO-2 isoform X2

    5. XM_054364194.1 → XP_054220169.1  tight junction protein ZO-2 isoform X1

    6. XM_054364198.1 → XP_054220173.1  tight junction protein ZO-2 isoform X1

    7. XM_054364200.1 → XP_054220175.1  tight junction protein ZO-2 isoform X1

    8. XM_054364199.1 → XP_054220174.1  tight junction protein ZO-2 isoform X1

    9. XM_054364201.1 → XP_054220176.1  tight junction protein ZO-2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001170630.1: Suppressed sequence

      Description
      NM_001170630.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UDY2.2 GenPept UniProtKB/Swiss-Prot:Q9UDY2

    Gene LinkOut

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