ZNF326 zinc finger protein 326 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF326provided by HGNC
Official Full Name: zinc finger protein 326provided by HGNC
Primary source: HGNC:HGNC:14104
See related: Ensembl:ENSG00000162664 MIM:614601; AllianceGenome:HGNC:14104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZIRD; ZAN75; Zfp326; dJ871E2.1
Summary: Enables RNA polymerase II complex binding activity. Involved in regulation of DNA-templated transcription elongation and regulation of RNA splicing. Located in nucleoplasm. Part of DBIRD complex. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 6.2), endometrium (RPKM 3.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p22.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (89995110..90035533)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (89838332..89878758)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (90460669..90501092)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32.
Title: MicroRNA-136-5p regulates gemcitabine resistance in pancreatic cancer via down-regulating ZNF32.
A long non-coding RNA OLBC15 promotes triple-negative breast cancer progression via enhancing ZNF326 degradation.
Title: A long non-coding RNA OLBC15 promotes triple-negative breast cancer progression via enhancing ZNF326 degradation.
Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
Title: Transcription Factor ZNF326 Upregulates the Expression of ERCC1 and HDAC7 and its Clinicopathologic Significance in Glioma.
Studied role of zinc finger protein 326 (ZNF326) in promotion of excision repair cross-complementation group 1 (ERCC1) expression in non-small cell lung cancer (NSCLC) cells.
Title: ZNF326 promotes proliferation of non-small cell lung cancer cells by regulating ERCC1 expression.
Data provide evidence that the high nuclear expression of ZNF326 in breast cancer was closely related to advanced pTNM staging, positive lymph node metastasis, and poor prognosis in patients with breast cancer. ZNF326 promotes proliferation, invasiveness, and xenograft formation by upregulating MMP7, EMT, and cell cycle-related factors by interacting with DBC1.
Title: ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1.
High ZNF326 expression is associated with glioma.
Title: ZNF326 promotes malignant phenotype of glioma by up-regulating HDAC7 expression and activating Wnt pathway.
Data indicate that ZNF326 is an interaction partner and substrate of the PRMT5/WDR77 complex.
Title: The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.
involvement of the Zfp326 and ZNF326 genes in antidepressant treatment response
Title: Convergent evidence from mouse and human studies suggests the involvement of zinc finger protein 326 gene in antidepressant treatment response.
data indicate that the DBIRD complex (consisting of DBC1 and ZNF326) acts at the interface between mRNP particles and RNAPII, integrating transcript elongation with the regulation of alternative splicing
Title: DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Zinc finger protein 326 (ZNF326) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69517 (e-PCR)
- UniSTS:90546

RH48327 (e-PCR)
- UniSTS:26616

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DBIRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DBIRD complex	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DBIRD complex subunit ZNF326

Names: ZNF-protein interacting with nuclear mRNPs and DBC1; zinc finger protein interacting with mRNPs and DBC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320185.2 → NP_001307114.1 DBIRD complex subunit ZNF326 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 4, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AK303707, AL161797, BC014899, BU676987, CN299618

Consensus CDS

CCDS81351.1

UniProtKB/TrEMBL

A0A0A0MRN4

Related

ENSP00000359476.2, ENST00000370447.3

Conserved Domains (1) summary

pfam04988
Location:223 → 388

AKAP95; A-kinase anchoring protein 95 (AKAP95)
NM_181781.4 → NP_861446.2 DBIRD complex subunit ZNF326 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AK303707, AL161797, BC014899, BC038454, BU676987, CN299618

UniProtKB/Swiss-Prot

Q5BKZ1

Conserved Domains (1) summary

pfam04988
Location:106 → 271

AKAP95; A-kinase anchoring protein 95 (AKAP95)
NM_182975.4 → NP_892020.1 DBIRD complex subunit ZNF326 isoform 3

See identical proteins and their annotated locations for NP_892020.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 3' exon structure and differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter C-terminus compared to isoform 1.

Source sequence(s)

AK000410, BC053888, CN299618

Consensus CDS

CCDS728.1

UniProtKB/Swiss-Prot

Q5BKZ1

Related

ENSP00000355318.5, ENST00000361911.9
NM_182976.4 → NP_892021.1 DBIRD complex subunit ZNF326 isoform 1

See identical proteins and their annotated locations for NP_892021.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK303707, AL161797, BC090866, BU676987, CN299618

Consensus CDS

CCDS727.1

UniProtKB/Swiss-Prot

A8MYX1, B4DLN0, B4E179, Q5BKZ1, Q5VW93, Q5VW94, Q5VW96, Q5VW97, Q6NSA2, Q7Z638, Q7Z6C2

Related

ENSP00000340796.4, ENST00000340281.9

Conserved Domains (1) summary

pfam04988
Location:312 → 477

AKAP95; A-kinase anchoring protein 95 (AKAP95)