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    TNFAIP1 TNF alpha induced protein 1 [ Homo sapiens (human) ]

    Gene ID: 7126, updated on 6-May-2024

    Summary

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    Official Symbol
    TNFAIP1provided by HGNC
    Official Full Name
    TNF alpha induced protein 1provided by HGNC
    Primary source
    HGNC:HGNC:11894
    See related
    Ensembl:ENSG00000109079 MIM:191161; AllianceGenome:HGNC:11894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B12; B61; EDP1; BTBD34; hBACURD2
    Summary
    This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 21.1), spleen (RPKM 20.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28335761..28347009)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29277609..29288860)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26662787..26674035)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 55 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:26609113-26610312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26644505-26645330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11921 Neighboring gene transmembrane protein 97 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11922 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:26662195-26662386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8335 Neighboring gene intraflagellar transport 20 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26671214-26671717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26672221-26672724 Neighboring gene uncharacterized LOC124903963 Neighboring gene DNA polymerase delta interacting protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:26683953-26684715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11924 Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of TNF-α induced protein 1 in the activation of pro-apoptotic proteins. Tang X, et al. Hum Cell, 2021 Jul. PMID 33909263
    2. Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-κB pathway. Zhang CL, et al. Oncol Rep, 2014 Sep. PMID 24969828
    3. Functional characterization of the promoter region of human TNFAIP1 gene. Liu M, et al. Mol Biol Rep, 2010 Apr. PMID 19593659
    4. [Expression profile in the cell lines of human TNFAIP1 gene]. Yang LP, et al. Yi Chuan, 2006 Aug. PMID 16870576
    5. Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. Ubalee R, et al. Tissue Antigens, 2001 Dec. PMID 11929592

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.
      Title: HECTD2/TNFAIP1 Axis Regulating the p38/JNK Pathway to Promote an Inflammatory Response in Renal Cell Carcinoma Cells.
    2. Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination.
      Title: Neuronal-specific TNFAIP1 ablation attenuates postoperative cognitive dysfunction via targeting SNAP25 for K48-linked ubiquitination.
    3. TNFAIP1 Is Upregulated in APP/PS1 Mice and Promotes Apoptosis in SH-SY5Y Cells by Binding to RhoB.
      Title: TNFAIP1 Is Upregulated in APP/PS1 Mice and Promotes Apoptosis in SH-SY5Y Cells by Binding to RhoB.
    4. The role of TNF-alpha induced protein 1 in the activation of pro-apoptotic proteins.
      Title: The role of TNF-α induced protein 1 in the activation of pro-apoptotic proteins.
    5. The CRL3(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.
      Title: The CRL3(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.
    6. Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.
      Title: Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.
    7. Tumor necrosis factor alpha-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks nuclear factor-kappaB activation in hepatocellular carcinoma.
      Title: Tumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks nuclear factor-κB activation in hepatocellular carcinoma.
    8. CREB is a negative regulator of the TNFAIP1 gene.
      Title: Transcription factor cyclic adenosine monophosphate responsive element binding protein negatively regulates tumor necrosis factor alpha-induced protein 1 expression.
    9. TNFAIP1 plays an important role in mediating miR-15a dependent biological functions in osteosarcoma.
      Title: MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells.
    10. MiR-181a played a critical role in regulating pancreatic cancer growth and migration, likely interacting with TNFAIP1.
      Title: Interaction between microRNA-181a and TNFAIP1 regulates pancreatic cancer proliferation and migration.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2317

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Names
    BTB/POZ domain-containing protein TNFAIP1
    tumor necrosis factor, alpha induced protein 1
    tumor necrosis factor, alpha-induced protein 1 (endothelial)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021137.5 → NP_066960.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_066960.1

      Status: REVIEWED

      Source sequence(s)
      BC003694
      Consensus CDS
      CCDS11227.1
      UniProtKB/Swiss-Prot
      B7Z6M4, Q13829, Q5TZQ1
      Related
      ENSP00000226225.2, ENST00000226225.7
      Conserved Domains (1) summary
      cd18401
      Location:26 → 129
      BTB_POZ_TNFAIP1_BACURD2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28335761..28347009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024993.3 → XP_016880482.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      29277609..29288860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317033.1 → XP_054173008.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13829.1 GenPept UniProtKB/Swiss-Prot:Q13829

    Gene LinkOut

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