U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CNOT7 CCR4-NOT transcription complex subunit 7 [ Homo sapiens (human) ]

    Gene ID: 29883, updated on 29-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CNOT7provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 7provided by HGNC
    Primary source
    HGNC:HGNC:14101
    See related
    Ensembl:ENSG00000198791 MIM:604913; AllianceGenome:HGNC:14101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAF1; CAF-1; Caf1a; hCAF-1
    Summary
    The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CNOT7 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (17224966..17246857, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (17492557..17514454, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17082475..17104366, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18960 Neighboring gene uncharacterized LOC107986918 Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2 Neighboring gene NANOG hESC enhancer GRCh37_chr8:17090642-17091144 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:17104115-17104963 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene myotubularin related protein 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_102346 Neighboring gene Sharpr-MPRA regulatory region 2048 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:17193352-17194551 Neighboring gene uncharacterized LOC102724838 Neighboring gene Sharpr-MPRA regulatory region 14094

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Alternative splicing of CNOT7 diversifies CCR4-NOT functions. Chapat C, et al. Nucleic Acids Res, 2017 Aug 21. PMID 28591869, Free PMC Article
    2. Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer. Flanagan J, et al. Int J Cancer, 2003 Sep 10. PMID 12845644
    3. CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma. Ren C, et al. FEBS Open Bio, 2020 May. PMID 32160402, Free PMC Article
    4. CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease. Li J, et al. Biochem Biophys Res Commun, 2024 Aug 20. PMID 38772212
    5. CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway. Yu J, et al. Life Sci, 2021 Mar 1. PMID 33412213

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease.
      Title: CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease.
    2. Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.
      Title: Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology.
    3. Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.
      Title: Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.
    4. CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma.
      Title: CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma.
    5. Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
      Title: Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma.
    6. CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway.
      Title: CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway.
    7. Data show that incorporation of ATP-dependent RNA helicase eIF4A-2 (eIF4A2) into the CCR4-NOT complex inhibits CCR4-NOT transcription complex subunit 7 (CNOT7) deadenylation activity.
      Title: DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.
    8. Active 1-hydroxy-xanthines inhibit both isolated Caf1 (CNOT7) enzyme and human Caf1-containing complexes that also contain the second nuclease subunit Ccr4 (CNOT6L) to a similar extent, indicating that the active site of the Caf1 nuclease subunit does not undergo substantial conformational change when bound to other Ccr4-Not subunits.
      Title: 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.
    9. Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover
      Title: Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
    10. MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7.
      Title: A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables piRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in piRNA-mediated gene silencing by mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in intracellular non-membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CCR4-NOT transcription complex subunit 7
    Names
    BTG1-binding factor 1
    CCR4-associated factor 1
    carbon catabolite repressor protein (CCR4)-associative factor 1
    NP_001309016.1
    NP_001309017.1
    NP_001309018.1
    NP_001309019.1
    NP_001309020.1
    NP_001309021.1
    NP_001309022.1
    NP_001309023.1
    NP_001309024.1
    NP_001309025.1
    NP_001309026.1
    NP_001309027.1
    NP_001309028.1
    NP_001309029.1
    NP_037486.2
    NP_473367.2
    XP_005273538.1
    XP_047277685.1
    XP_047277686.1
    XP_047277687.1
    XP_054216351.1
    XP_054216352.1
    XP_054216353.1
    XP_054216354.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322087.2 → NP_001309016.1  CCR4-NOT transcription complex subunit 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AW448990, BC070187, BI094365, BI458088, DA695885, DA752620
      Consensus CDS
      CCDS55202.1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1 → 244
      CAF1; CAF1 family ribonuclease

    2. NM_001322088.2 → NP_001309017.1  CCR4-NOT transcription complex subunit 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AL833642, AW448990, BC070187, BI094365, DA695885
      Consensus CDS
      CCDS55202.1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1 → 244
      CAF1; CAF1 family ribonuclease

    3. NM_001322089.2 → NP_001309018.1  CCR4-NOT transcription complex subunit 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AC091050, AW448990, BC070187, BI094365, BI464507, DA695885, HY002876
      Consensus CDS
      CCDS55202.1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1 → 244
      CAF1; CAF1 family ribonuclease

    4. NM_001322090.2 → NP_001309019.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, BC007315, BC070187, BI458088, DA752620
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1
      UniProtKB/TrEMBL
      B3KM57
      Conserved Domains (1) summary
      cl23804
      Location:1 → 279
      CAF1; CAF1 family ribonuclease

    5. NM_001322091.2 → NP_001309020.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, AL833642, BC007315, BC070187
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1
      UniProtKB/TrEMBL
      B3KM57
      Conserved Domains (1) summary
      cl23804
      Location:1 → 279
      CAF1; CAF1 family ribonuclease

    6. NM_001322092.2 → NP_001309021.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, AL833642, BC007315, BC070187, BI458088
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1
      UniProtKB/TrEMBL
      B3KM57
      Conserved Domains (1) summary
      cl23804
      Location:1 → 279
      CAF1; CAF1 family ribonuclease

    7. NM_001322093.2 → NP_001309022.1  CCR4-NOT transcription complex subunit 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
      Source sequence(s)
      AC091050, BC007315, BC070187, BI464507, DA752620
      UniProtKB/TrEMBL
      B3KM57
      Conserved Domains (1) summary
      cl23804
      Location:1 → 301
      CAF1; CAF1 family ribonuclease

    8. NM_001322094.2 → NP_001309023.1  CCR4-NOT transcription complex subunit 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate splice site in the 3' terminal exon and thus contains an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL528251, BC007315, BC070187, DA752620
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1 → 245
      CAF1; CAF1 family ribonuclease

    9. NM_001322095.2 → NP_001309024.1  CCR4-NOT transcription complex subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
      Source sequence(s)
      AC091050, BC007315, BC070187, DA508565, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:2 → 198
      CAF1; CAF1 family ribonuclease

    10. NM_001322096.2 → NP_001309025.1  CCR4-NOT transcription complex subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
      Source sequence(s)
      AC091050, BC007315, BC070187, DA720240, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:2 → 198
      CAF1; CAF1 family ribonuclease

    11. NM_001322097.2 → NP_001309026.1  CCR4-NOT transcription complex subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) contains alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
      Source sequence(s)
      AC091050, AL833642, BC007315, BC070187, DA720240
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:2 → 198
      CAF1; CAF1 family ribonuclease

    12. NM_001322098.2 → NP_001309027.1  CCR4-NOT transcription complex subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
      Source sequence(s)
      AW448990, BC070187, BI094365, DA508565, DA695885, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:2 → 163
      CAF1; CAF1 family ribonuclease

    13. NM_001322099.2 → NP_001309028.1  CCR4-NOT transcription complex subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
      Source sequence(s)
      AW448990, BC070187, BI094365, DA695885, DA720240, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:2 → 163
      CAF1; CAF1 family ribonuclease

    14. NM_001322100.2 → NP_001309029.1  CCR4-NOT transcription complex subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
      Source sequence(s)
      AW448990, BC070187, BI094365, BI458088, DA508565, DA695885
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:2 → 163
      CAF1; CAF1 family ribonuclease

    15. NM_013354.7 → NP_037486.2  CCR4-NOT transcription complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_037486.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, BC007315, BC070187, DA752620
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1
      UniProtKB/TrEMBL
      B3KM57
      Related
      ENSP00000355279.4, ENST00000361272.9
      Conserved Domains (1) summary
      cl23804
      Location:1 → 279
      CAF1; CAF1 family ribonuclease

    16. NM_054026.4 → NP_473367.2  CCR4-NOT transcription complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_473367.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AW448990, BC070187, BI094365, DA695885, DA752620
      Consensus CDS
      CCDS55202.1
      UniProtKB/TrEMBL
      Q96IQ6
      Related
      ENSP00000429093.1, ENST00000523917.5
      Conserved Domains (1) summary
      cl23804
      Location:1 → 244
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      17224966..17246857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421730.1 → XP_047277686.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

    2. XM_047421731.1 → XP_047277687.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

    3. XM_005273481.4 → XP_005273538.1  CCR4-NOT transcription complex subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_005273538.1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1
      UniProtKB/TrEMBL
      B3KM57
      Conserved Domains (1) summary
      cl23804
      Location:1 → 279
      CAF1; CAF1 family ribonuclease

    4. XM_047421729.1 → XP_047277685.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      17492557..17514454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360379.1 → XP_054216354.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

    2. XM_054360378.1 → XP_054216353.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

    3. XM_054360376.1 → XP_054216351.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1

    4. XM_054360377.1 → XP_054216352.1  CCR4-NOT transcription complex subunit 7 isoform X1

      UniProtKB/Swiss-Prot
      A8MZM5, B3KMP1, B3KN35, D3DSP6, G3V108, Q7Z530, Q9UIV1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UIV1.3 GenPept UniProtKB/Swiss-Prot:Q9UIV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous