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    PGLYRP2 peptidoglycan recognition protein 2 [ Homo sapiens (human) ]

    Gene ID: 114770, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PGLYRP2provided by HGNC
    Official Full Name
    peptidoglycan recognition protein 2provided by HGNC
    Primary source
    HGNC:HGNC:30013
    See related
    Ensembl:ENSG00000161031 MIM:608199; AllianceGenome:HGNC:30013
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha
    Summary
    This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
    Expression
    Restricted expression toward liver (RPKM 52.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See PGLYRP2 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15468645..15479501, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15593641..15604523, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15579456..15590312, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WIZ zinc finger Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14185 Neighboring gene microRNA 1470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14188 Neighboring gene RAS protein activator like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15618980-15619480 Neighboring gene staufen double-stranded RNA binding protein 1 pseudogene Neighboring gene cytochrome P450 family 4 subfamily F member 22 Neighboring gene MPRA-validated peak3387 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14191 Neighboring gene cytochrome P450 family 4 subfamily F member 23, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10285

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors. Li X, et al. J Biol Chem, 2006 Jul 28. PMID 16714290
    2. Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography. De Pauw P, et al. Protein Expr Purif, 1995 Jun. PMID 7663175
    3. Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. Zhang Y, et al. Biochim Biophys Acta, 2005 Aug 31. PMID 16054449
    4. Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway. Wang H, et al. Infect Immun, 2005 Nov. PMID 16239516, Free PMC Article
    5. Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population. Luan M, et al. Neurosci Lett, 2022 Apr 1. PMID 35218888

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population.
      Title: Association of PGLYRP2 gene polymorphism and sporadic Parkinson's disease in northern Chinese Han population.
    2. PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
      Title: PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus.
    3. Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
      Title: Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
    4. Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
      Title: Serum sCD14, PGLYRP2 and FGA as potential biomarkers for multidrug-resistant tuberculosis based on data-independent acquisition and targeted proteomics.
    5. Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
      Title: Tumor-Derived Peptidoglycan Recognition Protein 2 Predicts Survival and Antitumor Immune Responses in Hepatocellular Carcinoma.
    6. The expression of IL-36gamma by oral epithelial cells in response to P. gingivalis might enable the subsequent autocrine stimulation of PGLYRP2 expression. Our data identify how IL-36gamma may promote oral mucosal homeostasis by regulating PGLYRP2 expression.
      Title: Regulation of the Peptidoglycan Amidase PGLYRP2 in Epithelial Cells by Interleukin-36γ.
    7. a significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported.
      Title: A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.
    8. This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease.
      Title: Peptidoglycan recognition protein genes and risk of Parkinson's disease.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    10. Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain
      Title: [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells].
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan immune receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidoglycan immune receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological process involved in interaction with host IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of natural killer cell differentiation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide amidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetylmuramoyl-L-alanine amidase
    Names
    peptidoglycan recognition protein L
    peptidoglycan recognition protein long
    NP_001350475.1
    NP_443122.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363546.1 → NP_001350475.1  N-acetylmuramoyl-L-alanine amidase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK055882, AY358156, BC144238
      Consensus CDS
      CCDS86718.1
      Related
      ENSP00000292609.3, ENST00000292609.8
      Conserved Domains (1) summary
      smart00701
      Location:380 → 525
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    2. NM_052890.4 → NP_443122.3  N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

      See identical proteins and their annotated locations for NP_443122.3

      Status: VALIDATED

      Source sequence(s)
      AF384856, DB041324
      Consensus CDS
      CCDS12330.2
      UniProtKB/Swiss-Prot
      A8K050, A8K8C7, B2RMZ2, B7ZM33, Q68CK1, Q96N74, Q96PD5, Q9UC60
      Related
      ENSP00000345968.4, ENST00000340880.5
      Conserved Domains (1) summary
      smart00701
      Location:380 → 525
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15468645..15479501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      15593641..15604523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PD5.1 GenPept UniProtKB/Swiss-Prot:Q96PD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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