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    VIRMA vir like m6A methyltransferase associated [ Homo sapiens (human) ]

    Gene ID: 25962, updated on 5-Nov-2024

    Summary

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    Official Symbol
    VIRMAprovided by HGNC
    Official Full Name
    vir like m6A methyltransferase associatedprovided by HGNC
    Primary source
    HGNC:HGNC:24500
    See related
    Ensembl:ENSG00000164944 MIM:616447; AllianceGenome:HGNC:24500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSTP054; fSAP121; KIAA1429
    Summary
    Enables RNA binding activity. Involved in mRNA processing. Located in RNA N6-methyladenosine methyltransferase complex; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 11.6), ovary (RPKM 8.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See VIRMA in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94487689..94553469, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (95612521..95678291, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95499917..95565697, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4X pseudogene 10 Neighboring gene RAD54 homolog B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:95447028-95447528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19366 Neighboring gene NANOG hESC enhancer GRCh37_chr8:95456748-95457280 Neighboring gene fibrinogen silencer binding protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:95480258-95480884 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:95480885-95481510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27631 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:95546863-95547362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27632 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene VIRMA divergent transcript Neighboring gene long intergenic non-protein coding RNA 2894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The component of the m(6)A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors. Miranda-Gonçalves V, et al. J Exp Clin Cancer Res, 2021 Aug 25. PMID 34446080, Free PMC Article
    2. KIAA1429 mediates epithelial mesenchymal transition in sorafenib-resistant hepatocellular carcinoma through m6A methylation modification. Kuang Y, et al. Cancer Med, 2023 Mar. PMID 36420693, Free PMC Article
    3. Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer. Chen H, et al. Biomol Biomed, 2024 Oct 17. PMID 38843497,
    4. m6A 'writer' KIAA1429 regulates the proliferation and migration of endothelial cells in atherosclerosis. Rong J, et al. Mol Biotechnol, 2023 Jul. PMID 36463391, Free PMC Article
    5. KIAA1429 promotes tumorigenesis and gefitinib resistance in lung adenocarcinoma by activating the JNK/ MAPK pathway in an m(6)A-dependent manner. Lin X, et al. Drug Resist Updat, 2023 Jan. PMID 36493511

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N6-Methyladenosine Methyltransferase Component KIAA1429 Is a Potential Target of Cancer Therapy.
      Title: N6-Methyladenosine Methyltransferase Component KIAA1429 Is a Potential Target of Cancer Therapy.
    2. KIAA1429 regulates lung adenocarcinoma proliferation and metastasis through the PI3K/AKT pathway by modulating ARHGAP30 expression.
      Title: KIAA1429 regulates lung adenocarcinoma proliferation and metastasis through the PI3K/AKT pathway by modulating ARHGAP30 expression.
    3. KIAA1429 Induces m6A Modification of LINC01106 to Enhance the Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3 Pathway.
      Title: KIAA1429 Induces m6A Modification of LINC01106 to Enhance the Malignancy of Lung Adenocarcinoma Cells via the JAK/STAT3 Pathway.
    4. VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.
      Title: VIRMA promotes the progression of head and neck squamous cell carcinoma by regulating UBR5 mRNA and m6A levels.
    5. Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer.
      Title: Role and mechanism of KIAA1429 in regulating cellular ferroptosis and radioresistance in colorectal cancer.
    6. Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3beta.
      Title: Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β.
    7. KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
      Title: KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
    8. Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification.
      Title: Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification.
    9. KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
      Title: KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
    10. KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m[6] A-dependent posttranscriptional modification of SLC7A11.
      Title: KIAA1429 protects hepatocellular carcinoma cells from ferroptotic cell death with a m(6) A-dependent posttranscriptional modification of SLC7A11.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138493, MGC141940, DKFZp434I116, DKFZp781B2117

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein virilizer homolog
    Names
    functional spliceosome-associated protein 121
    virilizer homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015496.5 → NP_056311.2  protein virilizer homolog isoform 1

      See identical proteins and their annotated locations for NP_056311.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA731668, AB037850, AC023632, AL832487, BC113380
      Consensus CDS
      CCDS34923.1
      UniProtKB/Swiss-Prot
      Q2M1N0, Q69YN4, Q6AHX9, Q6NT78, Q7Z6C7, Q8IXH4, Q9BTH4, Q9H9C9, Q9NWR3, Q9P2B8, Q9UFW1
      Related
      ENSP00000297591.5, ENST00000297591.10
      Conserved Domains (2) summary
      pfam15502
      Location:1703 → 1808
      MPLKIP; M-phase-specific PLK1-interacting protein
      pfam15912
      Location:5 → 235
      VIR_N; Virilizer, N-terminal

    2. NM_183009.3 → NP_892121.1  protein virilizer homolog isoform 2

      See identical proteins and their annotated locations for NP_892121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF116724, BC113380
      Consensus CDS
      CCDS47894.1
      UniProtKB/Swiss-Prot
      Q69YN4
      Related
      ENSP00000398390.2, ENST00000421249.2
      Conserved Domains (1) summary
      pfam15912
      Location:5 → 235
      VIR_N; Virilizer, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      94487689..94553469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421677.1 → XP_047277633.1  protein virilizer homolog isoform X1

    2. XM_047421678.1 → XP_047277634.1  protein virilizer homolog isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      95612521..95678291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360260.1 → XP_054216235.1  protein virilizer homolog isoform X1

    2. XM_054360261.1 → XP_054216236.1  protein virilizer homolog isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69YN4.2 GenPept UniProtKB/Swiss-Prot:Q69YN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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