RPRD1B regulation of nuclear pre-mRNA domain containing 1B [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPRD1Bprovided by HGNC
Official Full Name: regulation of nuclear pre-mRNA domain containing 1Bprovided by HGNC
Primary source: HGNC:HGNC:16209
See related: Ensembl:ENSG00000101413 MIM:614694; AllianceGenome:HGNC:16209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: K-H; CREPT; NET60; C20orf77; Kub5-Hera; dJ1057B20.2
Summary: Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in several processes, including RNA polymerase II promoter clearance; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bone marrow (RPKM 7.4), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (38033746..38092364)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (39758090..39816692)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (36662148..36720766)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer.
Title: Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer.
Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma.
Title: Immunohistochemical expression levels of cyclin D1 and CREPT reflect the course and prognosis in oral precancerous lesions and squamous cell carcinoma.
CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma.
Title: CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma.
CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
Title: CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study.
Title: RPRD1B is a potentially molecular target for diagnosis and prevention of human papillomavirus E6/E7 infection-induced cervical cancer: A case-control study.
CREPT is required for murine stem cell maintenance during intestinal regeneration.
Title: CREPT is required for murine stem cell maintenance during intestinal regeneration.
MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B.
Title: MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B.
Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer.
Title: Overexpression of cell-cycle related and expression-elevated protein in tumor (CREPT) in malignant cervical cancer.
Crosstalk between RNA Pol II C-terminal domain acetylation and phosphorylation via RPRD1B protein and its isoforms has been reported.
Title: Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins.
these results demonstrate that CREPT exerts an oncogenic role in glioma and its expression is regulated by miR-596.
Title: CREPT promotes glioma cell proliferation and invasion by activating Wnt/β-catenin pathway and is a novel target of microRNA-596.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z94355 (e-PCR)
- UniSTS:68378

WI-22173 (e-PCR)
- UniSTS:64037

RH120583 (e-PCR)
- UniSTS:132416

A002U21 (e-PCR)
- UniSTS:42443

SHGC-80717 (e-PCR)
- UniSTS:170223

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II C-terminal domain binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II promoter clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription preinitiation complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulation of nuclear pre-mRNA domain-containing protein 1B

Names: Ku70-binding protein 5-Hera; cell-cycle related and expression-elevated protein in tumor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021215.4 → NP_067038.1 regulation of nuclear pre-mRNA domain-containing protein 1B

See identical proteins and their annotated locations for NP_067038.1

Status: VALIDATED

Source sequence(s)

AK092567, BC033629, BP359144

Consensus CDS

CCDS13301.1

UniProtKB/Swiss-Prot

Q1WDE7, Q6PKF4, Q9NQG5

Related

ENSP00000362532.4, ENST00000373433.9

Conserved Domains (2) summary

cd17012
Location:3 → 131

CID_RPRD1B; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 1B

pfam16566
Location:178 → 324

CREPT; Cell-cycle alteration and expression-elevated protein in tumor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

38033746..38092364

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047440346.1 → XP_047296302.1 regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1
XM_047440347.1 → XP_047296303.1 regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2

Related

ENSP00000416420.2, ENST00000449186.2

Alternate T2T-CHM13v2.0

Genomic

NC_060944.1 Alternate T2T-CHM13v2.0

Range

39758090..39816692

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054323787.1 → XP_054179762.1 regulation of nuclear pre-mRNA domain-containing protein 1B isoform X1
XM_054323788.1 → XP_054179763.1 regulation of nuclear pre-mRNA domain-containing protein 1B isoform X2