ADGRA2 adhesion G protein-coupled receptor A2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRA2provided by HGNC
Official Full Name: adhesion G protein-coupled receptor A2provided by HGNC
Primary source: HGNC:HGNC:17849
See related: Ensembl:ENSG00000020181 MIM:606823; AllianceGenome:HGNC:17849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TEM5; GPR124
Summary: Predicted to enable G protein-coupled receptor activity. Involved in canonical Wnt signaling pathway. Located in intracellular membrane-bounded organelle and plasma membrane. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p11.23

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (37796883..37844896)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (38073278..38121297)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (37654401..37702414)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells.
Title: Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells.
An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.
Title: An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.
Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.
Title: Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.
Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients
Title: Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.
Increases and decreases in GPR124 expression in glioblastoma cells reduce cell proliferation by differentially altering the duration mitotic progression. GPR124 interacts with ch-TOG, a known regulator of both microtubule (MT)-plus-end assembly and mitotic progression. Changes in GPR124 expression and ch-TOG similarly affect MT assembly.
Title: GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation.
Data suggest that GPR124 promotes cell adhesion via interaction with Elmo1-Dock180 and intersectin 1/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 = G-protein coupled receptor 124; Elmo1 = ELMO domain-containing protein 1; Dock180 = dedicator of cytokinesis protein 1 180 kDa)
Title: Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.
Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib.
Title: miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124.
Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase.
Title: Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase.
TEM5 expression during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of proliferation in endothelial cells.
Title: Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.
Proteolytically processed soluble tumor endothelial marker TEM5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans
Title: Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci at chromosomes 13, 19 and 20 influence age at natural menopause. EBI GWAS Catalog EBI GWAS CatalogPubMed
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC33756 (e-PCR)
- UniSTS:32009

SHGC-152364 (e-PCR)
- UniSTS:177488

AFMb057wg5 (e-PCR)
- UniSTS:67965

GPR124_2026 (e-PCR)
- UniSTS:280706

NoName (e-PCR)
- UniSTS:492454

D8S1722 (e-PCR)
- UniSTS:34011

RH18231 (e-PCR)
- UniSTS:509

Clone Names

FLJ14390, KIAA1531, DKFZp434C211, DKFZp434J0911

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of blood-brain barrier	ISS Inferred from Sequence or Structural Similarity more info
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Wnt signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor A2

Names: G-protein coupled receptor 124; tumor endothelial marker 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032777.10 → NP_116166.9 adhesion G protein-coupled receptor A2 precursor

See identical proteins and their annotated locations for NP_116166.9

Status: VALIDATED

Source sequence(s)

AC130304, AC138356, AF378755, AI346793, AL110244, AY090637, DA569569

Consensus CDS

CCDS6097.2

UniProtKB/Swiss-Prot

A6H8W3, D3DSW4, Q8N3R1, Q8TEM3, Q96KB2, Q96PE1, Q9P1Z7, Q9UFY4

Related

ENSP00000406367.2, ENST00000412232.3

Conserved Domains (8) summary

smart00082
Location:192 → 227

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:87 → 190

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:86 → 109

LRR_1; leucine-rich repeat [structural motif]

pfam01825
Location:708 → 752

GPS; GPCR proteolysis site, GPS, motif

pfam13855
Location:88 → 144

LRR_8; Leucine rich repeat

cl02422
Location:351 → 417

HRM; Hormone receptor domain

cl11960
Location:257 → 343

Ig; Immunoglobulin domain

cl21561
Location:778 → 946

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

37796883..37844896

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544481.3 → XP_011542783.1 adhesion G protein-coupled receptor A2 isoform X1

Conserved Domains (8) summary

smart00082
Location:192 → 227

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:87 → 190

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:86 → 109

LRR_1; leucine-rich repeat [structural motif]

pfam01825
Location:708 → 752

GPS; GPCR proteolysis site, GPS, motif

pfam13855
Location:88 → 144

LRR_8; Leucine rich repeat

cl02422
Location:351 → 417

HRM; Hormone receptor domain

cl11960
Location:257 → 343

Ig; Immunoglobulin domain

cl21561
Location:778 → 969

7tm_4; Olfactory receptor
XM_011544483.3 → XP_011542785.1 adhesion G protein-coupled receptor A2 isoform X3

See identical proteins and their annotated locations for XP_011542785.1

Conserved Domains (8) summary

smart00082
Location:192 → 227

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:87 → 190

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:86 → 109

LRR_1; leucine-rich repeat [structural motif]

pfam01825
Location:708 → 752

GPS; GPCR proteolysis site, GPS, motif

pfam13855
Location:88 → 144

LRR_8; Leucine rich repeat

cl02422
Location:351 → 417

HRM; Hormone receptor domain

cl11960
Location:257 → 343

Ig; Immunoglobulin domain

cl21561
Location:778 → 916

7tm_4; Olfactory receptor
XM_011544482.3 → XP_011542784.1 adhesion G protein-coupled receptor A2 isoform X2

Conserved Domains (8) summary

smart00082
Location:168 → 203

LRRCT; Leucine rich repeat C-terminal domain

sd00031
Location:88 → 109

LRR_1; leucine-rich repeat [structural motif]

pfam01825
Location:684 → 728

GPS; GPCR proteolysis site, GPS, motif

pfam12799
Location:110 → 149

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:88 → 142

LRR_8; Leucine rich repeat

cl02422
Location:327 → 393

HRM; Hormone receptor domain

cl11960
Location:233 → 319

Ig; Immunoglobulin domain

cl21561
Location:754 → 945

7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

38073278..38121297

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054360257.1 → XP_054216232.1 adhesion G protein-coupled receptor A2 isoform X1
XM_054360259.1 → XP_054216234.1 adhesion G protein-coupled receptor A2 isoform X3
XM_054360258.1 → XP_054216233.1 adhesion G protein-coupled receptor A2 isoform X2