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    MYO7A myosin VIIA [ Homo sapiens (human) ]

    Gene ID: 4647, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MYO7Aprovided by HGNC
    Official Full Name
    myosin VIIAprovided by HGNC
    Primary source
    HGNC:HGNC:7606
    See related
    Ensembl:ENSG00000137474 MIM:276903; AllianceGenome:HGNC:7606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA
    Summary
    This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in adrenal (RPKM 8.3), testis (RPKM 6.5) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYO7A in Genome Data Viewer
    Location:
    11q13.5
    Exon count:
    56
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77128246..77215241)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77058823..77147851)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (76839292..76926286)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76777177-76777677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76797624-76798572 Neighboring gene calpain 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76824170-76824764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76824765-76825360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76825361-76825954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76837978-76838700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76838701-76839424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76840147-76840870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76842316-76843037 Neighboring gene olfactory marker protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76851056-76851622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:76893658-76894158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76902287-76902788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76902789-76903288 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene TOMM20 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and functional study of a new missense mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11). Sang Q, et al. PLoS One, 2013. PMID 23383098, Free PMC Article
    2. [Gene mapping for autosomal dominant nonsyndromic hearing loss DFNA11]. Yuan H, et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2007 Jun. PMID 17702415
    3. Analysis of MYO7A in a Moroccan family with Usher syndrome type 1B: novel loss-of-function mutation and non-pathogenicity of p.Y1719C. Boulouiz R, et al. Mol Vis, 2007 Oct 2. PMID 17960123
    4. Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function. Riazuddin S, et al. Hum Mutat, 2008 Apr. PMID 18181211
    5. Impacts of Usher syndrome type IB mutations on human myosin VIIa motor function. Watanabe S, et al. Biochemistry, 2008 Sep 9. PMID 18700726, Free PMC Article

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of two major isoforms of MYO7A in the retina: Considerations for gene therapy of Usher syndrome type 1B.
      Title: Expression of two major isoforms of MYO7A in the retina: Considerations for gene therapy of Usher syndrome type 1B.
    2. Dispersed DNA variants underlie hearing loss in South Florida's minority population.
      Title: Dispersed DNA variants underlie hearing loss in South Florida's minority population.
    3. New splice site mutations in MYO7A causing Usher syndrome type 1: a study on a Chinese consanguineous family.
      Title: New splice site mutations in MYO7A causing Usher syndrome type 1: a study on a Chinese consanguineous family.
    4. Identification of novel missense mutation related with non-syndromic sensorineural deafness, DFNA11 in korean family by NGS.
      Title: Identification of novel missense mutation related with non-syndromic sensorineural deafness, DFNA11 in korean family by NGS.
    5. Novel compound heterozygous synonymous and missense variants in the MYO7A gene identified by next-generation sequencing in a Chinese family with nonsyndromic hearing loss.
      Title: Novel compound heterozygous synonymous and missense variants in the MYO7A gene identified by next-generation sequencing in a Chinese family with nonsyndromic hearing loss.
    6. Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease.
      Title: Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease.
    7. The Study of a 231 French Patient Cohort Significantly Extends the Mutational Spectrum of the Two Major Usher Genes MYO7A and USH2A.
      Title: The Study of a 231 French Patient Cohort Significantly Extends the Mutational Spectrum of the Two Major Usher Genes MYO7A and USH2A.
    8. Genotype-phenotype correlation in patients with Usher syndrome and pathogenic variants in MYO7A: implications for future clinical trials.
      Title: Genotype-phenotype correlation in patients with Usher syndrome and pathogenic variants in MYO7A: implications for future clinical trials.
    9. Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families.
      Title: Next-Generation Sequencing Identifies Pathogenic Variants in HGF, POU3F4, TECTA, and MYO7A in Consanguineous Pakistani Deaf Families.
    10. Retinal findings in pediatric patients with Usher syndrome Type 1 due to mutations in MYO7A gene.
      Title: Retinal findings in pediatric patients with Usher syndrome Type 1 due to mutations in MYO7A gene.
    Submit: New GeneRIF Correction See all GeneRIFs (95)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in auditory receptor cell stereocilium organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cochlea development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in equilibrioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye photoreceptor cell development IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mechanoreceptor differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phagolysosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pigment granule transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin VII complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor connecting cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stereocilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stereocilium base ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in upper tip-link density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-VIIa
    Names
    myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009086.2 RefSeqGene

      Range
      5001..91996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1420

    mRNA and Protein(s)

    1. NM_000260.4 → NP_000251.3  unconventional myosin-VIIa isoform 1

      See identical proteins and their annotated locations for NP_000251.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AP000752, BG108466, U34227, U39226, U55208
      Consensus CDS
      CCDS53683.1
      UniProtKB/Swiss-Prot
      B9A011, F8VUN5, P78427, Q13321, Q13402, Q14785, Q92821, Q92822
      Related
      ENSP00000386331.3, ENST00000409709.9
      Conserved Domains (14) summary
      smart00015
      Location:766 → 787
      IQ; Calmodulin-binding motif
      smart00139
      Location:1763 → 1896
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:60 → 741
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1903 → 2115
      B41; Band 4.1 homologues
      cd13198
      Location:1468 → 1604
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:2111 → 2206
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:1363 → 1463
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:79 → 729
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:2013 → 2115
      FERM_M; FERM central domain
      pfam05672
      Location:866 → 935
      MAP7; MAP7 (E-MAP-115) family
      pfam09379
      Location:1262 → 1301
      FERM_N; FERM N-terminal domain
      pfam15743
      Location:808 → 946
      SPATA1_C; Spermatogenesis-associated C-terminus
      cl17036
      Location:1605 → 1669
      SH3; Src Homology 3 domain superfamily
      cl19107
      Location:866 → 934
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_001127180.2 → NP_001120652.1  unconventional myosin-VIIa isoform 2

      See identical proteins and their annotated locations for NP_001120652.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AP000752, BG108466, U39226, U55208
      Consensus CDS
      CCDS53684.1
      UniProtKB/Swiss-Prot
      Q13402
      Related
      ENSP00000392185.2, ENST00000458637.6
      Conserved Domains (13) summary
      smart00015
      Location:766 → 787
      IQ; Calmodulin-binding motif
      smart00139
      Location:1725 → 1858
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:60 → 741
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1865 → 2077
      B41; Band 4.1 homologues
      cd13198
      Location:1468 → 1566
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:2073 → 2166
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd14473
      Location:1363 → 1463
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:79 → 729
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:1975 → 2077
      FERM_M; FERM central domain
      pfam05672
      Location:866 → 935
      MAP7; MAP7 (E-MAP-115) family
      pfam09379
      Location:1262 → 1301
      FERM_N; FERM N-terminal domain
      cl17036
      Location:1567 → 1631
      SH3; Src Homology 3 domain superfamily
      cl19107
      Location:866 → 934
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    3. NM_001369365.1 → NP_001356294.1  unconventional myosin-VIIa isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000752, AP001855, KF511157
      Consensus CDS
      CCDS91543.1
      Related
      ENSP00000386635.2, ENST00000409619.6
      Conserved Domains (11) summary
      smart00015
      Location:755 → 776
      IQ; Calmodulin-binding motif
      smart00139
      Location:1714 → 1847
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1854 → 2066
      B41; Band 4.1 homologues
      COG3064
      Location:785 → 955
      TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]
      cd13198
      Location:1457 → 1555
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd13199
      Location:2062 → 2157
      FERM_C2_MyoVII; FERM domain C-lobe, repeat 2, of Myosin VII (MyoVII, Myo7)
      cd01381
      Location:68 → 718
      MYSc_Myo7; class VII myosin, motor domain
      pfam05672
      Location:846 → 923
      MAP7; MAP7 (E-MAP-115) family
      cd17092
      Location:1246 → 1344
      FERM1_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 1, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
      cd17093
      Location:1852 → 1949
      FERM2_F1_Myosin-VII; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain 2, F1 sub-domain, found in Myosin-VIIa, Myosin-VIIb, and similar proteins
      cl17036
      Location:1556 → 1620
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      77128246..77215241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545044.3 → XP_011543346.1  unconventional myosin-VIIa isoform X5

      Conserved Domains (13) summary
      smart00015
      Location:766 → 787
      IQ; Calmodulin-binding motif
      smart00139
      Location:1763 → 1896
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:60 → 741
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1903 → 2115
      B41; Band 4.1 homologues
      cd13198
      Location:1468 → 1604
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd14473
      Location:1363 → 1463
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:79 → 729
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:2013 → 2115
      FERM_M; FERM central domain
      pfam05672
      Location:866 → 935
      MAP7; MAP7 (E-MAP-115) family
      pfam09379
      Location:1262 → 1301
      FERM_N; FERM N-terminal domain
      pfam15743
      Location:808 → 946
      SPATA1_C; Spermatogenesis-associated C-terminus
      cl17036
      Location:1605 → 1669
      SH3; Src Homology 3 domain superfamily
      cl19107
      Location:866 → 934
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. XM_047426970.1 → XP_047282926.1  unconventional myosin-VIIa isoform X10

    3. XM_047426971.1 → XP_047282927.1  unconventional myosin-VIIa isoform X13

    4. XM_017017780.2 → XP_016873269.1  unconventional myosin-VIIa isoform X4

    5. XM_017017788.2 → XP_016873277.1  unconventional myosin-VIIa isoform X19

    6. XM_017017784.2 → XP_016873273.1  unconventional myosin-VIIa isoform X9

    7. XM_017017786.2 → XP_016873275.1  unconventional myosin-VIIa isoform X12

    8. XM_017017778.2 → XP_016873267.1  unconventional myosin-VIIa isoform X2

    9. XM_017017779.2 → XP_016873268.1  unconventional myosin-VIIa isoform X3

    10. XM_011545046.3 → XP_011543348.2  unconventional myosin-VIIa isoform X1

    11. XM_017017781.2 → XP_016873270.1  unconventional myosin-VIIa isoform X6

    12. XM_017017785.2 → XP_016873274.1  unconventional myosin-VIIa isoform X11

    13. XM_017017782.2 → XP_016873271.1  unconventional myosin-VIIa isoform X7

    14. XM_017017783.2 → XP_016873272.1  unconventional myosin-VIIa isoform X8

    15. XM_047426972.1 → XP_047282928.1  unconventional myosin-VIIa isoform X15

    16. XM_047426974.1 → XP_047282930.1  unconventional myosin-VIIa isoform X17

    17. XM_017017787.2 → XP_016873276.1  unconventional myosin-VIIa isoform X18

    18. XM_047426973.1 → XP_047282929.1  unconventional myosin-VIIa isoform X16

    19. XM_011545050.3 → XP_011543352.1  unconventional myosin-VIIa isoform X14

      Conserved Domains (12) summary
      smart00015
      Location:680 → 701
      IQ; Calmodulin-binding motif
      smart00139
      Location:1675 → 1808
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:10 → 655
      MYSc; Myosin. Large ATPases
      smart00295
      Location:1815 → 2027
      B41; Band 4.1 homologues
      cd13198
      Location:1418 → 1516
      FERM_C1_MyoVII; FERM domain C-lobe, repeat 1, of Myosin VII (MyoVII/Myo7)
      cd14473
      Location:1313 → 1413
      FERM_B-lobe; FERM domain B-lobe
      cd01381
      Location:10 → 643
      MYSc_Myo7; class VII myosin, motor domain
      pfam00373
      Location:1925 → 2027
      FERM_M; FERM central domain
      pfam05672
      Location:780 → 849
      MAP7; MAP7 (E-MAP-115) family
      pfam09379
      Location:1176 → 1215
      FERM_N; FERM N-terminal domain
      cl17036
      Location:1517 → 1581
      SH3; Src Homology 3 domain superfamily
      cl19107
      Location:780 → 848
      SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    RNA

    1. XR_001747888.2 RNA Sequence

    2. XR_001747889.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      77058823..77147851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368856.1 → XP_054224831.1  unconventional myosin-VIIa isoform X5

    2. XM_054368861.1 → XP_054224836.1  unconventional myosin-VIIa isoform X10

    3. XM_054368864.1 → XP_054224839.1  unconventional myosin-VIIa isoform X13

    4. XM_054368869.1 → XP_054224844.1  unconventional myosin-VIIa isoform X31

    5. XM_054368868.1 → XP_054224843.1  unconventional myosin-VIIa isoform X30

    6. XM_054368857.1 → XP_054224832.1  unconventional myosin-VIIa isoform X23

    7. XM_054368853.1 → XP_054224828.1  unconventional myosin-VIIa isoform X20

    8. XM_054368854.1 → XP_054224829.1  unconventional myosin-VIIa isoform X21

    9. XM_054368852.1 → XP_054224827.1  unconventional myosin-VIIa isoform X16

    10. XM_054368862.1 → XP_054224837.1  unconventional myosin-VIIa isoform X27

    11. XM_054368866.1 → XP_054224841.1  unconventional myosin-VIIa isoform X29

    12. XM_054368858.1 → XP_054224833.1  unconventional myosin-VIIa isoform X24

    13. XM_054368859.1 → XP_054224834.1  unconventional myosin-VIIa isoform X25

    14. XM_054368863.1 → XP_054224838.1  unconventional myosin-VIIa isoform X28

    15. XM_054368855.1 → XP_054224830.1  unconventional myosin-VIIa isoform X22

    16. XM_054368860.1 → XP_054224835.1  unconventional myosin-VIIa isoform X26

    17. XM_054368870.1 → XP_054224845.1  unconventional myosin-VIIa isoform X32

    18. XM_054368867.1 → XP_054224842.1  unconventional myosin-VIIa isoform X16

    19. XM_054368865.1 → XP_054224840.1  unconventional myosin-VIIa isoform X14

    RNA

    1. XR_008488401.1 RNA Sequence

    2. XR_008488400.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001127179.2: Suppressed sequence

      Description
      NM_001127179.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13402.2 GenPept UniProtKB/Swiss-Prot:Q13402

    Gene LinkOut

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