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    FZD10 frizzled class receptor 10 [ Homo sapiens (human) ]

    Gene ID: 11211, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FZD10provided by HGNC
    Official Full Name
    frizzled class receptor 10provided by HGNC
    Primary source
    HGNC:HGNC:4039
    See related
    Ensembl:ENSG00000111432 MIM:606147; AllianceGenome:HGNC:4039
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fz10; FzE7; CD350; FZ-10; hFz10
    Summary
    This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]
    Orthologs
    mouse all
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    Genomic context

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    See FZD10 in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (130162464..130165740)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (130199607..130202883)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (130647009..130650285)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903088 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25699 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25704 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25722 Neighboring gene FZD10 antisense divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:130645489-130646055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:130646056-130646622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:130648209-130649204 Neighboring gene NANOG hESC enhancer GRCh37_chr12:130649290-130649835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:130667832-130668510 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:130677479-130677979 Neighboring gene Sharpr-MPRA regulatory region 11699 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:130682728-130683228 Neighboring gene ribosomal protein S20 pseudogene 30 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25789 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25816 Neighboring gene uncharacterized LOC107984480

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways. Wang J, et al. Gastroenterology, 2023 May. PMID 36764493
    2. Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB. Shin HW, et al. Korean J Hepatol, 2009 Dec. PMID 20037267
    3. Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors. Carmon KS, et al. Anal Biochem, 2010 Jun 15. PMID 20227380, Free PMC Article
    4. Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. Nagayama S, et al. Cancer Sci, 2009 Mar. PMID 19134005, Free PMC Article
    5. N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance. Fukumoto T, et al. Cancer Res, 2019 Jun 1. PMID 30967398, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/beta-Catenin and Hippo Signaling Pathways.
      Title: N6-Methyladenosine-Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells' Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways.
    2. [Exosomal FZD10 derived from non-small cell lung cancer cells promotes angiogenesis of human umbilical venous endothelial cells in vitro].
      Title: [Exosomal FZD10 derived from non-small cell lung cancer cells promotes angiogenesis of human umbilical venous endothelial cells in vitro].
    3. Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.
      Title: Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10.
    4. SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/beta-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.
      Title: SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt/β-catenin signaling pathway via miR92b-3p/FZD10 in nasopharyngeal carcinoma cells.
    5. A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell Line.
      Title: A Possible Role of FZD10 Delivering Exosomes Derived from Colon Cancers Cell Lines in Inducing Activation of Epithelial-Mesenchymal Transition in Normal Colon Epithelial Cell Line.
    6. N(6)-methylation of adenosine of FZD10 mRNA contributes to PARP inhibitor resistance in the ovarian cancer cells.
      Title: N(6)-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance.
    7. The tumor associated antigen hFZD10 produced as a fusion protein with mTEM7 could be used to enrich scFv antibodies from a yeast display library.
      Title: A fusion-protein approach enabling mammalian cell production of tumor targeting protein domains for therapeutic development.
    8. the selective expression of FZD10 in brain vascular endothelial cells points at a potential role of FZD10-Galpha13 signalling in central nervous system angiogenesis.
      Title: FZD(10)-Gα(13) signalling axis points to a role of FZD(10) in CNS angiogenesis.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
    10. there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10
      Title: Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of a quantitative disordered gambling trait.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to retinoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    frizzled-10
    Names
    frizzled 10, seven transmembrane spanning receptor
    frizzled family receptor 10
    frizzled homolog 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007197.4 → NP_009128.1  frizzled-10 precursor

      See identical proteins and their annotated locations for NP_009128.1

      Status: REVIEWED

      Source sequence(s)
      AB027464, AC026336, AI697875, BC070037, BC074997
      Consensus CDS
      CCDS9267.1
      UniProtKB/Swiss-Prot
      Q9ULW2
      UniProtKB/TrEMBL
      Q6NSL8
      Related
      ENSP00000229030.4, ENST00000229030.5
      Conserved Domains (2) summary
      cd07462
      Location:30 → 156
      CRD_FZ10; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 10 (Fz10) receptor
      cd15037
      Location:217 → 535
      7tmF_FZD10; class F frizzled subfamily 10, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      130162464..130165740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      130199607..130202883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULW2.1 GenPept UniProtKB/Swiss-Prot:Q9ULW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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