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    CD300LG CD300 molecule like family member g [ Homo sapiens (human) ]

    Gene ID: 146894, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CD300LGprovided by HGNC
    Official Full Name
    CD300 molecule like family member gprovided by HGNC
    Primary source
    HGNC:HGNC:30455
    See related
    Ensembl:ENSG00000161649 MIM:610520; AllianceGenome:HGNC:30455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLM9; CLM-9; TREM4; TREM-4; NEPMUCIN
    Summary
    Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in fat (RPKM 45.4), placenta (RPKM 12.3) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CD300LG in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43847176..43863639)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44699730..44716193)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41924544..41941007)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MAGUK p55 scaffold protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8569 Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41943686-41943858 Neighboring gene Sharpr-MPRA regulatory region 5434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959115-41959616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959617-41960116 Neighboring gene MAGUK p55 scaffold protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41991041-41991541 Neighboring gene uncharacterized LOC105371787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41994398-41995219 Neighboring gene family with sequence similarity 215 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression Depression of CD300LG-γ in Human Pulmonary Carcinoma. Zhai S, et al. Monoclon Antib Immunodiagn Immunother, 2016 Apr. PMID 26977771
    2. Blood pressure levels in male carriers of Arg82Cys in CD300LG. Støy J, et al. PLoS One, 2014. PMID 25314291, Free PMC Article
    3. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. Umemoto E, et al. J Exp Med, 2006 Jun 12. PMID 16754720, Free PMC Article
    4. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Takatsu H, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16876123
    5. The CD300 molecules regulate monocyte and dendritic cell functions. Clark GJ, et al. Immunobiology, 2009. PMID 19592130

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in multivesicular body membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    CMRF35-like molecule 9
    Names
    CD300 antigen-like family member G
    triggering receptor expressed on myeloid cells 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168322.2 → NP_001161794.1  CMRF35-like molecule 9 isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AK309938
      Consensus CDS
      CCDS54131.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000442368.1, ENST00000539718.5
      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    2. NM_001168323.2 → NP_001161795.1  CMRF35-like molecule 9 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC015937, AK298112, AK309938
      Consensus CDS
      CCDS54132.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000366408.3, ENST00000377203.8
      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    3. NM_001168324.2 → NP_001161796.1  CMRF35-like molecule 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001161796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC015937, AF427619
      Consensus CDS
      CCDS54133.1
      UniProtKB/Swiss-Prot
      Q6UXG3
      Related
      ENSP00000293396.7, ENST00000293396.12
      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    4. NM_001411122.1 → NP_001398051.1  CMRF35-like molecule 9 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC007993, AC015937
      Consensus CDS
      CCDS92332.1
      UniProtKB/TrEMBL
      A0A8V8TQK5
      Related
      ENSP00000515157.1, ENST00000700726.1

    5. NM_145273.4 → NP_660316.2  CMRF35-like molecule 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_660316.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC007993, AC015937, AK298112, AY358364, BC025395
      Consensus CDS
      CCDS11470.1
      UniProtKB/Swiss-Prot
      B4DNY5, F5H7P9, F8W9M3, Q6UXG3, Q8IX38, Q8IX39, Q8TA95
      Related
      ENSP00000321005.3, ENST00000317310.5
      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43847176..43863639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721721.4 → XP_006721784.1  CMRF35-like molecule 9 isoform X1

      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    2. XM_005257075.4 → XP_005257132.1  CMRF35-like molecule 9 isoform X3

      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    3. XM_006721722.4 → XP_006721785.1  CMRF35-like molecule 9 isoform X2

      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    4. XM_005257076.4 → XP_005257133.1  CMRF35-like molecule 9 isoform X5

      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    5. XM_011524384.4 → XP_011522686.1  CMRF35-like molecule 9 isoform X4

      Conserved Domains (2) summary
      cd05716
      Location:24 → 113
      Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
      smart00410
      Location:22 → 124
      IG_like; Immunoglobulin like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44699730..44716193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315209.1 → XP_054171184.1  CMRF35-like molecule 9 isoform X1

    2. XM_054315211.1 → XP_054171186.1  CMRF35-like molecule 9 isoform X3

    3. XM_054315210.1 → XP_054171185.1  CMRF35-like molecule 9 isoform X2

    4. XM_054315213.1 → XP_054171188.1  CMRF35-like molecule 9 isoform X5

    5. XM_054315212.1 → XP_054171187.1  CMRF35-like molecule 9 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UXG3.2 GenPept UniProtKB/Swiss-Prot:Q6UXG3

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