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    SLC22A6 solute carrier family 22 member 6 [ Homo sapiens (human) ]

    Gene ID: 9356, updated on 28-Oct-2024

    Summary

    Official Symbol
    SLC22A6provided by HGNC
    Official Full Name
    solute carrier family 22 member 6provided by HGNC
    Primary source
    HGNC:HGNC:10970
    See related
    Ensembl:ENSG00000197901 MIM:607582; AllianceGenome:HGNC:10970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OAT1; PAHT; HOAT1; ROAT1
    Summary
    The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward kidney (RPKM 150.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC22A6 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62976597..62984967, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62965855..62974245, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62744069..62752439, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902683 Neighboring gene uncharacterized LOC105369333 Neighboring gene cholinergic receptor muscarinic 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62689159-62689693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62692895-62693660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62701569-62702077 Neighboring gene RNA, 7SL, cytoplasmic 259, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62751576-62752126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62765923-62766840 Neighboring gene solute carrier family 22 member 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62782318-62783172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62784863-62785362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62787753-62788334 Neighboring gene PTTG1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ55736, MGC45260

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric proximal tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in organic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in organic anion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prostaglandin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in renal tubular secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal tubular secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium-independent organic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium-independent organic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 6
    Names
    PAH transporter
    hPAHT
    hROAT1
    organic anion transporter 1
    para-aminohippurate transporter
    renal organic anion transporter 1
    solute carrier family 22 (organic anion transporter), member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004790.5NP_004781.2  solute carrier family 22 member 6 isoform a

      See identical proteins and their annotated locations for NP_004781.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also called hOAT1-1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB009697, AI017670, DA629600
      Consensus CDS
      CCDS31591.1
      UniProtKB/Swiss-Prot
      A8MY93, B2D0R6, O95187, O95742, Q4U2R8, Q7LDA0, Q8N192, Q9NQA6, Q9NQC2, Q9UBG6, Q9UEQ8
      UniProtKB/TrEMBL
      B3KRM3
      Related
      ENSP00000367102.3, ENST00000377871.7
      Conserved Domains (2) summary
      cd06174
      Location:135505
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11515
      2A0119; cation transport protein
    2. NM_153276.3NP_695008.1  solute carrier family 22 member 6 isoform b

      See identical proteins and their annotated locations for NP_695008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also called OAT1-2) lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      BC033682
      Consensus CDS
      CCDS8041.1
      UniProtKB/TrEMBL
      B3KRM3
      Related
      ENSP00000353597.4, ENST00000360421.9
      Conserved Domains (1) summary
      TIGR00898
      Location:11515
      2A0119; cation transport protein
    3. NM_153277.3NP_695009.1  solute carrier family 22 member 6 isoform c

      See identical proteins and their annotated locations for NP_695009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also called OAT1-3) lacks two alternate in-frame segments compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
      Source sequence(s)
      AI017670, AJ251529, DA628191, DB320467
      Consensus CDS
      CCDS44632.1
      UniProtKB/TrEMBL
      B3KRM3
      Related
      ENSP00000396401.2, ENST00000458333.6
      Conserved Domains (2) summary
      cd06174
      Location:135456
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11471
      2A0119; cation transport protein
    4. NM_153278.3NP_695010.1  solute carrier family 22 member 6 isoform d

      See identical proteins and their annotated locations for NP_695010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also called OAT1-4) lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
      Source sequence(s)
      AB009697, AI017670, AJ271205, DA628191
      Consensus CDS
      CCDS44631.1
      UniProtKB/TrEMBL
      B3KRM3
      Related
      ENSP00000404441.2, ENST00000421062.2
      Conserved Domains (2) summary
      cd06174
      Location:135456
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11471
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62976597..62984967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018562.3XP_016874051.1  solute carrier family 22 member 6 isoform X1

      UniProtKB/TrEMBL
      B3KRM3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62965855..62974245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370531.1XP_054226506.1  solute carrier family 22 member 6 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153279.1: Suppressed sequence

      Description
      NM_153279.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.