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    RNVU1-18 RNA, variant U1 small nuclear 18 [ Homo sapiens (human) ]

    Gene ID: 26863, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RNVU1-18provided by HGNC
    Official Full Name
    RNA, variant U1 small nuclear 18provided by HGNC
    Primary source
    HGNC:HGNC:37496
    See related
    Ensembl:ENSG00000206737 AllianceGenome:HGNC:37496
    Gene type
    snRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    U1.15; U1P15; RNU1-5; RNU1P1; RNU1P9; U1P101; vU1.18; RNU1-25; RNU1-25P
    Summary
    Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See RNVU1-18 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (143729407..143729570, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (142801537..142801700, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149224058..149224221, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Asn (anticodon GTT) 22-1 Neighboring gene RNA, variant U1 small nuclear 23 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149222669-149223600 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149223601-149224533 Neighboring gene tRNA-Asn (anticodon GTT) 6-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:149233351-149233850 Neighboring gene NBPF member 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human U1 RNA pseudogenes may be generated by both DNA- and RNA-mediated mechanisms. Denison RA, et al. Mol Cell Biol, 1982 Jul. PMID 6085956, Free PMC Article
    2. Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transposition. Bernstein LB, et al. Mol Cell Biol, 1985 Sep. PMID 3837185, Free PMC Article
    3. Human U1 loci: genes for human U1 RNA have dramatically similar genomic environments. Manser T, et al. Cell, 1982 May. PMID 6179629
    4. Differentially expressed, variant U1 snRNAs regulate gene expression in human cells. O'Reilly D, et al. Genome Res, 2013 Feb. PMID 23070852, Free PMC Article
    5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • RNA, U1 small nuclear 25, pseudogene
    • RNA, U1 small nuclear 5
    • RNA, U1 small nuclear pseudogene 1
    • RNA, U1 small nuclear pseudogene 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_004400.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC239800
      Related
      ENST00000384010.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      143729407..143729570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791756.1 Reference GRCh38.p14 PATCHES

      Range
      957786..957949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      142801537..142801700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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