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    ASAP1-IT1 ASAP1 intronic transcript 1 [ Homo sapiens (human) ]

    Gene ID: 29065, updated on 17-Sep-2024

    Summary

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    Official Symbol
    ASAP1-IT1provided by HGNC
    Official Full Name
    ASAP1 intronic transcript 1provided by HGNC
    Primary source
    HGNC:HGNC:24998
    See related
    AllianceGenome:HGNC:24998
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASAP1IT; HSPC054; ASAP1-IT; ASAP1IT1; DDEF1IT1; NCRNA00050
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    Genomic context

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    See ASAP1-IT1 in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (130295355..130296533, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (131421981..131423158, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131307601..131308779, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:131216140-131217109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27982 Neighboring gene uncharacterized LOC124902027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27984 Neighboring gene NANOG hESC enhancer GRCh37_chr8:131323031-131323532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131345596-131346175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131370073-131371035 Neighboring gene uncharacterized LOC124902026 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:131380037-131380536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131388200-131388776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131431296-131431799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19554 Neighboring gene Sharpr-MPRA regulatory region 3250 Neighboring gene uncharacterized LOC105375758 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131540148-131541347

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway. Guo L, et al. Biomed Pharmacother, 2018 Jul. PMID 29653361
    2. Long non-coding RNA ASAP1-IT1 promotes cell proliferation, invasion and metastasis through the PTEN/AKT signaling axis in non-small cell lung cancer. Zhang L, et al. Eur Rev Med Pharmacol Sci, 2018 Jan. PMID 29364481
    3. Long noncoding RNA ASAP1-IT1 promotes cancer stemness and predicts a poor prognosis in patients with bladder cancer. Yang L, et al. Neoplasma, 2017. PMID 28895409
    4. Long non-coding RNAs, ASAP1-IT1, FAM215A, and LINC00472, in epithelial ovarian cancer. Fu Y, et al. Gynecol Oncol, 2016 Dec. PMID 27667152, Free PMC Article
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interference on ASAP1-IT1 expression could inhibit the proliferation of NSCLC cells, while the transwell experiment showed that the interference on ASAP1-IT1 expression could block the migration and invasion ability of NSCLC cells. ASAP1-IT1 could regulate the biological behaviors of NSCLC cells through phosphatase and tensin homolog deleted on chromosome ten (PTEN)/serine-threonine kinase (AKT) pathway.
      Title: Long non-coding RNA ASAP1-IT1 promotes cell proliferation, invasion and metastasis through the PTEN/AKT signaling axis in non-small cell lung cancer.
    2. ASAP1-IT1 could positively modulate Smo and Gli1 in Cholangiocarcinoma.
      Title: LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • ASAP1 intronic transcript (non-protein coding)
    • ASAP1 intronic transcript 1 (non-protein coding)
    • ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 intronic transcript 1 (non-protein coding)
    • DDEF1 intronic transcript 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002765.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009682

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      130295355..130296533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      131421981..131423158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014152.1: Suppressed sequence

      Description
      NM_014152.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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