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    LOC440895 two pore channel 3 pseudogene [ Homo sapiens (human) ]

    Gene ID: 440895, updated on 17-Jun-2024

    Summary

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    Gene symbol
    LOC440895
    Gene description
    two pore channel 3 pseudogene
    See related
    Ensembl:ENSG00000290731
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 64.8), endometrium (RPKM 16.8) and 1 other tissue See more
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    Genomic context

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    See LOC440895 in Genome Data Viewer
    Location:
    2q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109947690..109968574)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (110705267..110726151)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LIMS3-LOC440895 readthrough Neighboring gene LIM zinc finger domain containing 3 Neighboring gene uncharacterized LOC105373547 Neighboring gene uncharacterized LOC124907865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110738405-110738906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:110738907-110739406 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1123 Neighboring gene zinc finger and BTB domain containing 45 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Degeneration of an intracellular ion channel in the primate lineage by relaxation of selective constraints. Cai X, et al. Mol Biol Evol, 2010 Oct. PMID 20463046
    2. Calcium signaling via two-pore channels: local or global, that is the question. Zhu MX, et al. Am J Physiol Cell Physiol, 2010 Mar. PMID 20018950, Free PMC Article
    3. An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. Brailoiu E, et al. J Biol Chem, 2010 Jan 29. PMID 19940116, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Readthrough LIMS3-LOC440895

    Readthrough gene: LIMS3-LOC440895, Included gene: LIMS3

    Clone Names

    • FLJ13238, DKFZp434E232

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027142.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) omits an internal exon, compared to variant 1.
      Source sequence(s)
      AA936147, AK310464, BI560270
      Related
      ENST00000433786.1

    2. NR_027143.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC013268

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      109947690..109968574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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