MIR1288 microRNA 1288 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1288provided by HGNC
Official Full Name: microRNA 1288provided by HGNC
Primary source: HGNC:HGNC:35363
See related: Ensembl:ENSG00000221355 miRBase:MI0006432; AllianceGenome:HGNC:35363
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN1288; hsa-mir-1288
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 17p11.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (16282014..16282088)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (16184320..16184394)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (16185328..16185402)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer.
Title: Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer.
the minor allele C of rs7219 is identified as a risk allele for Schizophrenia (SCZ) because it generates a binding site for miR-1288, thereby resulting in decreased expression of GRB2 and ultimately increasing the risk of SCZ.
Title: Rs7219 Regulates the Expression of GRB2 by Affecting miR-1288-Mediated Inhibition and Contributes to the Risk of Schizophrenia in the Chinese Han Population.
Ectopic expression of miR1288 promoted the prolife-ration, colony formation and anchorageindependent growth of GBM cells and miR1288 promoted cell proliferation of GBM by targeting ubiquitin carboxylterminal hydrolase (CYLD).
Title: MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression.
Overexpression of miR-1288 play a key role in the pathogenesis of oesophageal squamous cell carcinoma.
Title: Overexpression of microRNA-1288 in oesophageal squamous cell carcinoma.
Reduced expression of miR-1288 is associated with colorectal cancer.
Title: Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.