MIR1266 microRNA 1266 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1266provided by HGNC
Official Full Name: microRNA 1266provided by HGNC
Primary source: HGNC:HGNC:35334
See related: Ensembl:ENSG00000221052 miRBase:MI0006403; AllianceGenome:HGNC:35334
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN1266; mir-1266; hsa-mir-1266
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 15q21.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (52277117..52277200, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (50085399..50085482, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (52569314..52569397, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-1266-3p Suppresses Epithelial-Mesenchymal Transition in Colon Cancer by Targeting P4HA3.
Title: miR-1266-3p Suppresses Epithelial-Mesenchymal Transition in Colon Cancer by Targeting P4HA3.
Effect of miR-1266 on proliferation, invasion and migration of laryngeal squamous cell carcinoma by targeting CCL18.
Title: Effect of miR-1266 on proliferation, invasion and migration of laryngeal squamous cell carcinoma by targeting CCL18.
Low expression of microRNA-1266 promotes the occurrence and progression of colorectal cancer by directly targeting FTO.
Title: Low expression of microRNA-1266 promotes colorectal cancer progression via targeting FTO.
miR-1266 could inhibit cell proliferation and progression of papillary thyroid carcinoma via targeting FGFR2.
Title: MicroRNA-1266 suppresses papillary thyroid carcinoma cell metastasis and growth via targeting FGFR2.
High expression serum miR-1266 had lower overall survival rates than patients with miR-1266 low expression. MiR-1266 promoted cell viability, proliferation, migration and invasion by targeting DAB2IP. And miR-1266 could promote tumorigenesis in vivo. In conclusion, miR-1266 could be used as a new biomarker for diagnosis, prediction and treatment of cervical cancer in the future.
Title: MiR-1266 promotes cell proliferation, migration and invasion in cervical cancer by targeting DAB2IP.
Low miR1266 expression is associated with Prostate Cancer.
Title: miR-1266-5p and miR-185-5p Promote Cell Apoptosis in Human Prostate Cancer Cell Lines.
high miR-1266 levels might be a significant prognostic factor for recurrence/metastasis occurrence and tamoxifen response in estrogen receptor positive breast cancer cases.
Title: Association of miR-1266 with recurrence/metastasis potential in estrogen receptor positive breast cancer patients.
MiR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting TERT.
Title: miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.