TMEM26 transmembrane protein 26 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMEM26provided by HGNC
Official Full Name: transmembrane protein 26provided by HGNC
Primary source: HGNC:HGNC:28550
See related: Ensembl:ENSG00000196932 MIM:617803; AllianceGenome:HGNC:28550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression: Broad expression in spleen (RPKM 2.6), endometrium (RPKM 1.8) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q21.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (61406642..61453381, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (62263409..62310147, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (63166400..63213139, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of TMEM26 in disrupting tight junctions and activating NF-kappaB signaling to promote epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
Title: The role of TMEM26 in disrupting tight junctions and activating NF-κB signaling to promote epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
High TMEM26 expression was found to be associated with a higher risk of recurrence.
Title: Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response.
show novel expression of genes near regions of significantly associated SNPS, including TMEM26 and FOXA1 in airway epithelium and lung parenchyma, and ANK3 in alveolar macrophages in COPD
Title: Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies eight loci associated with blood pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178505.8 → NP_848600.2 transmembrane protein 26

See identical proteins and their annotated locations for NP_848600.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.

Source sequence(s)

AC068892, AW510476, CR749606

Consensus CDS

CCDS41530.1

UniProtKB/Swiss-Prot

Q6ZUK4, Q6ZVM0, Q8IVN9

Related

ENSP00000382237.3, ENST00000399298.8

Conserved Domains (1) summary

pfam09772
Location:3 → 303

Tmem26; Transmembrane protein 26

RNA

NR_134507.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) splices out a portion of the 3' terminal exon found in variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK125611, AW510476, CR749606
NR_134508.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains alternate 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC068892, BC042872, CR749606