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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_051989.2 RefSeqGene
- Range
-
37329..146605
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001346765.2 → NP_001333694.1 unconventional myosin-XVIIIa isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
- Source sequence(s)
-
AC005412, AC024619
-
NM_001346766.2 → NP_001333695.1 unconventional myosin-XVIIIa isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform c.
- Source sequence(s)
-
AC005412, AC024619
- Consensus CDS
-
CCDS92285.1
- UniProtKB/TrEMBL
-
A0A994J771
- Related
- ENSP00000515984.1, ENST00000704659.1
- Conserved Domains (3) summary
-
- COG5022
Location:393 → 1917
- COG5022; Myosin heavy chain [General function prediction only]
- cd00992
Location:218 → 308
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd01386
Location:431 → 1185
- MYSc_Myo18; class XVIII myosin, motor domain
-
NM_001346767.2 → NP_001333696.1 unconventional myosin-XVIIIa isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR and lacks three alternate in-frame exons compared to variant 3. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform c.
- Source sequence(s)
-
AC005412, AC024619, BC039612
- Consensus CDS
-
CCDS86587.1
- UniProtKB/Swiss-Prot
-
Q92614
- Related
- ENSP00000435932.1, ENST00000533112.5
-
NM_001346768.2 → NP_001333697.1 unconventional myosin-XVIIIa isoform f
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks an alternate in-frame exon and represents use of an alternate promoter, therefore differing in the 5' UTR and 5' coding sequence, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in an isoform (f) that lacks an alternate internal segment and has a shorter N-terminus, compared to isoform c.
- Source sequence(s)
-
AC024619
- UniProtKB/TrEMBL
-
B4DYM1
-
NM_078471.4 → NP_510880.2 unconventional myosin-XVIIIa isoform a
See identical proteins and their annotated locations for NP_510880.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) contains an alternate in-frame exon and lacks two alternate in-frame exons compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
- Source sequence(s)
-
AC005412, AC024619, BM544214, D86970
- Consensus CDS
-
CCDS45642.1
- UniProtKB/Swiss-Prot
- Q5H9U3, Q5QD01, Q5W9F9, Q5W9G1, Q8IXP8, Q92614
- Related
- ENSP00000437073.1, ENST00000527372.7
- Conserved Domains (7) summary
-
- smart00242
Location:400 → 1185
- MYSc; Myosin. Large ATPases
- cd00992
Location:218 → 308
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd01386
Location:419 → 1173
- MYSc_Myo18; class XVIII myosin, motor domain
- pfam00038
Location:1258 → 1583
- Filament; Intermediate filament protein
- pfam09755
Location:1558 → 1910
- DUF2046; Uncharacterized conserved protein H4 (DUF2046)
- pfam16043
Location:1756 → 1898
- DUF4795; Domain of unknown function (DUF4795)
- cl02488
Location:1389 → 1628
- SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
-
NM_203318.2 → NP_976063.1 unconventional myosin-XVIIIa isoform b
See identical proteins and their annotated locations for NP_976063.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
- Source sequence(s)
-
AC005412, AC024619, AF252258, BM544214, D86970
- Consensus CDS
-
CCDS45641.1
- Related
- ENSP00000434228.1, ENST00000531253.5
- Conserved Domains (3) summary
-
- COG5022
Location:381 → 1905
- COG5022; Myosin heavy chain [General function prediction only]
- cd00992
Location:218 → 308
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd01386
Location:419 → 1173
- MYSc_Myo18; class XVIII myosin, motor domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
29071122..29180398 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
30013842..30123093 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_004740.3: Suppressed sequence
- Description
- NM_004740.3: This RefSeq was removed because the gene is thought to be a part of the 3' end of another gene.