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    MRC1 mannose receptor C-type 1 [ Homo sapiens (human) ]

    Gene ID: 4360, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MRC1provided by HGNC
    Official Full Name
    mannose receptor C-type 1provided by HGNC
    Primary source
    HGNC:HGNC:7228
    See related
    Ensembl:ENSG00000260314 MIM:153618; AllianceGenome:HGNC:7228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1
    Summary
    The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
    Annotation information
    Note: In the NCBI Build 37.2 reference assembly, MRC1 and MRC1L1 are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. Two of the clones on which MRC1L1 was based (AL928580, BX255924) will be removed from the reference assembly and only MRC1 will be present in the assembly. [13 Feb 2013]
    Expression
    Broad expression in lung (RPKM 50.7), spleen (RPKM 28.0) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRC1 in Genome Data Viewer
    Location:
    10p12.33
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (17809348..17911164)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (17828682..17930487)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18098337..18200093)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:17685753-17686402 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:17713088-17713842 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:17715682-17716218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:17728822-17729322 Neighboring gene MPRA-validated peak889 silencer Neighboring gene signal transducing adaptor molecule Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:17829359-17829976 Neighboring gene transmembrane protein 236 Neighboring gene uncharacterized LOC124902600 Neighboring gene microRNA 511 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:18270087-18271286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3111 Neighboring gene solute carrier family 39 member 12 Neighboring gene SLC39A12 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:18324740-18325329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:18325330-18325918 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:18355421-18356620 Neighboring gene MPRA-validated peak890 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr10:18424852-18425818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11486 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. Zhang J, et al. J Leukoc Biol, 2005 Sep. PMID 16000387
    2. The sdLDL Reduces MRC1 Expression Level and Secretion of Histamin e in Differentiated M2-macrophages from Patients with Coronary Artery Stenosis. Yarnazari A, et al. Cardiovasc Hematol Disord Drug Targets, 2017 Jul 4. PMID 28059035
    3. Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. Feinberg H, et al. J Biol Chem, 2000 Jul 14. PMID 10779515
    4. Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis. Izumi G, et al. Fertil Steril, 2017 Jan. PMID 27793384
    5. The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization. Salazar F, et al. J Allergy Clin Immunol, 2016 Jun. PMID 26703454

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
      Title: Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
    2. Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
      Title: Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
    3. Soluble CD206 levels correlate with disease deterioration and predict prognosis of anti-MDA5 antibody-positive dermatomyositis related interstitial lung disease.
      Title: Soluble CD206 levels correlate with disease deterioration and predict prognosis of anti-MDA5 antibody-positive dermatomyositis related interstitial lung disease.
    4. CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis.
      Title: CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis.
    5. CD206[+]CD68[+] mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis.
      Title: CD206(+)CD68(+) mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis.
    6. Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters.
      Title: Human CD206+ macrophages associate with diabetes and adipose tissue lymphoid clusters.
    7. The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease.
      Title: The mannose receptor (CD206) identifies a population of colonic macrophages in health and inflammatory bowel disease.
    8. CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma.
      Title: CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma.
    9. Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis.
      Title: Increased Levels of Soluble CD206 Associated with Rapidly Progressive Interstitial Lung Disease in Patients with Dermatomyositis.
    10. The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer.
      Title: The myeloid cell biomarker EMR1 is ectopically expressed in colon cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of mannose receptor, C type 1 (MRC1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binds to mannose receptor on vaginal epithelial cells PubMed
    env Mannose receptor (MR) dimers bind to soluble monomeric and trimeric HIV envelope and to HIV virion in capture assay PubMed
    env Recombinant HIV-1 gp120 blocks Mannose Receptor-mediated phagocytosis in human and murine macrophages and microglial cells PubMed
    env HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin PubMed
    env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
    Nef nef HIV-1 Nef downregulates mannose receptor (MR) on the surface of macrophages and dendritic cells (DC); both NTLY and SDXXXL motifs in the cytoplasmic tail of MR are critical for the cell surface reduction of MR PubMed
    Tat tat HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters PubMed
    tat HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC181940

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D-mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cargo receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    macrophage mannose receptor 1
    Names
    C-type lectin domain family 13 member D
    human mannose receptor
    macrophage mannose receptor 1-like protein 1
    mannose receptor, C type 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047011.1 RefSeqGene

      Range
      5006..106822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002438.4 → NP_002429.1  macrophage mannose receptor 1 precursor

      See identical proteins and their annotated locations for NP_002429.1

      Status: REVIEWED

      Source sequence(s)
      AC069023, AL139238, AV659122, DC296466, J05550
      Consensus CDS
      CCDS7123.2
      UniProtKB/Swiss-Prot
      A5PKW3, P22897, Q5VSJ2, Q5VSK2
      UniProtKB/TrEMBL
      Q0Z8D6
      Related
      ENSP00000455897.1, ENST00000569591.3
      Conserved Domains (5) summary
      smart00059
      Location:161 → 209
      FN2; Fibronectin type 2 domain
      cd00037
      Location:659 → 779
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      smart00034
      Location:362 → 487
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:27 → 142
      RICIN; Ricin-type beta-trefoil
      cd00161
      Location:34 → 141
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      17809348..17911164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      17828682..17930487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001009567.1: Suppressed sequence

      Description
      NM_001009567.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22897.1 GenPept UniProtKB/Swiss-Prot:P22897

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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