FBXW11 F-box and WD repeat domain containing 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXW11provided by HGNC
Official Full Name: F-box and WD repeat domain containing 11provided by HGNC
Primary source: HGNC:HGNC:13607
See related: Ensembl:ENSG00000072803 MIM:605651; AllianceGenome:HGNC:13607
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Hos; BTRC2; FBW1B; Fbw11; BTRCP2; FBXW1B; NEDJED
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 22.1), heart (RPKM 11.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q35.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (171861549..172006638, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (172401847..172546952, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (171288553..171433642, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-kappaB pathway activation in pancreatitis and pancreatic cancer.
Title: E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.
Expression of FBXW11 in normal and disease-associated osteogenic cells.
Title: Expression of FBXW11 in normal and disease-associated osteogenic cells.
Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.
Title: Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.
F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A.
Title: F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A.
FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer.
Title: FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer.
The characteristics and roles of beta-TrCP1/2 in carcinogenesis.
Title: The characteristics and roles of β-TrCP1/2 in carcinogenesis.
MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling.
Title: MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling.
findings support the role of FBXW11 in multiple developmental processes, including those involving the brain, eye, digits, and jaw
Title: De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies.
Fbxw11 expression is upregulated in patients with ALL. High levels of Fbxw11 expression stimulate the proliferation of L1210 lymphocytic leukemia cells in vitro and promote tumor formation in vivo by regulating the cell cycle. Most importantly, activation of both the NF-kappaB and beta-catenin/TCF signaling pathways is involved in this process.
Title: Fbxw11 promotes the proliferation of lymphocytic leukemia cells through the concomitant activation of NF-κB and β-catenin/TCF signaling pathways.
USP9X promotes tumorigenesis and FBXW11 suppresses tumorigenesis through PTENalpha/beta.
Title: PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neurodevelopmental, jaw, eye, and digital syndrome MedGen: C5394477 OMIM: 618914 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2011-12-07) ClinGen Genome Curation Page Triplosensitivity Little evidence for dosage pathogenicity (Last evaluated 2011-12-07) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of F-box and WD repeat domain containing 11 (FBXW11) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Vpu	vpu	HIV-1 Vpu is identified to have a physical interaction with F-box and WD-40 domain protein 11 (FBXW11; FBW1B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
	vpu	Co-expression of HIV-1 Vpu with beta-TrCP2 induces degradation of total cellular CD4 content; Vpu-mediated CD4 down-modulation is inhibited by double silencing of beta-TrCP1 and beta-TrCP2	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5S429 (e-PCR), detects polymorphism
- UniSTS:150023

D5S429 (e-PCR), detects polymorphism
- UniSTS:75532

SHGC-82273 (e-PCR)
- UniSTS:104220

SHGC-173547 (e-PCR)
- UniSTS:185390

RH80538 (e-PCR)
- UniSTS:85048

G16891 (e-PCR)
- UniSTS:41298

RH10985 (e-PCR)
- UniSTS:62047

G42662 (e-PCR)
- UniSTS:94562

WI-14938 (e-PCR)
- UniSTS:61564

RH118656 (e-PCR)
- UniSTS:138149

bac51052T (e-PCR)
- UniSTS:181416

FBXW11__6861 (e-PCR)
- UniSTS:466172

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in brain morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule organizing center organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	NAS Non-traceable Author Statement more info	PubMed
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: F-box/WD repeat-containing protein 11

Names: F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 1B; beta-transducin repeat-containing protein 2; homologous to Slimb protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009275.2 RefSeqGene

Range

5236..150325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001378974.1 → NP_001365903.1 F-box/WD repeat-containing protein 11 isoform D

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Consensus CDS

CCDS93825.1

UniProtKB/TrEMBL

E5RGC1

Related

ENSP00000428753.2, ENST00000517395.6

Conserved Domains (4) summary

cd00200
Location:261 → 539

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:264 → 299

7WD40; WD40 repeat [structural motif]

pfam12125
Location:99 → 137

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:141 → 188

F-box-like
NM_001378975.1 → NP_001365904.1 F-box/WD repeat-containing protein 11 isoform E

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Conserved Domains (4) summary

cd00200
Location:238 → 516

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:241 → 276

7WD40; WD40 repeat [structural motif]

pfam12125
Location:78 → 116

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:120 → 165

F-box-like
NM_001378976.1 → NP_001365905.1 F-box/WD repeat-containing protein 11 isoform F

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Conserved Domains (4) summary

cd00200
Location:229 → 507

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:232 → 267

7WD40; WD40 repeat [structural motif]

pfam12125
Location:67 → 105

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:109 → 156

F-box-like
NM_001378977.1 → NP_001365906.1 F-box/WD repeat-containing protein 11 isoform G

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

UniProtKB/TrEMBL

B4DH70

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
NM_001378978.1 → NP_001365907.1 F-box/WD repeat-containing protein 11 isoform G

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

UniProtKB/TrEMBL

B4DH70

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
NM_001378979.1 → NP_001365908.1 F-box/WD repeat-containing protein 11 isoform H

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Conserved Domains (4) summary

cd00200
Location:208 → 486

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:211 → 246

7WD40; WD40 repeat [structural motif]

pfam12125
Location:46 → 84

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:88 → 135

F-box-like
NM_001378980.1 → NP_001365909.1 F-box/WD repeat-containing protein 11 isoform A

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Consensus CDS

CCDS47340.1

Conserved Domains (4) summary

cd00200
Location:206 → 484

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:209 → 244

7WD40; WD40 repeat [structural motif]

pfam12125
Location:44 → 82

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:86 → 133

F-box-like
NM_012300.3 → NP_036432.2 F-box/WD repeat-containing protein 11 isoform C

See identical proteins and their annotated locations for NP_036432.2

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Consensus CDS

CCDS34289.1

UniProtKB/Swiss-Prot

B2RC98, Q9P2S8, Q9P2S9, Q9UKB1, Q9Y4C6

Related

ENSP00000265094.5, ENST00000265094.9

Conserved Domains (4) summary

cd00200
Location:240 → 518

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:243 → 278

7WD40; WD40 repeat [structural motif]

pfam12125
Location:78 → 116

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:120 → 167

F-box-like
NM_033644.3 → NP_387448.2 F-box/WD repeat-containing protein 11 isoform B

See identical proteins and their annotated locations for NP_387448.2

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Consensus CDS

CCDS47341.1

UniProtKB/Swiss-Prot

Q9UKB1

Related

ENSP00000296933.6, ENST00000296933.10

Conserved Domains (4) summary

cd00200
Location:227 → 505

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:230 → 265

7WD40; WD40 repeat [structural motif]

pfam12125
Location:65 → 103

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:107 → 154

F-box-like
NM_033645.3 → NP_387449.2 F-box/WD repeat-containing protein 11 isoform A

See identical proteins and their annotated locations for NP_387449.2

Status: REVIEWED

Source sequence(s)

AC011387, AC011410, AC113342

Consensus CDS

CCDS47340.1

UniProtKB/Swiss-Prot

Q9UKB1

Related

ENSP00000377391.2, ENST00000393802.6

Conserved Domains (4) summary

cd00200
Location:206 → 484

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:209 → 244

7WD40; WD40 repeat [structural motif]

pfam12125
Location:44 → 82

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:86 → 133

F-box-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

171861549..172006638 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417023.1 → XP_047272979.1 F-box/WD repeat-containing protein 11 isoform X3
XM_017009279.2 → XP_016864768.1 F-box/WD repeat-containing protein 11 isoform X1
XM_005265857.2 → XP_005265914.1 F-box/WD repeat-containing protein 11 isoform X2

See identical proteins and their annotated locations for XP_005265914.1

Conserved Domains (4) summary

cd00200
Location:213 → 491

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:216 → 251

7WD40; WD40 repeat [structural motif]

pfam12125
Location:51 → 89

Beta-TrCP_D; D domain of beta-TrCP

pfam12937
Location:93 → 140

F-box-like

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

172401847..172546952 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054352218.1 → XP_054208193.1 F-box/WD repeat-containing protein 11 isoform X3
XM_054352216.1 → XP_054208191.1 F-box/WD repeat-containing protein 11 isoform X1
XM_054352217.1 → XP_054208192.1 F-box/WD repeat-containing protein 11 isoform X2