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    USP33 ubiquitin specific peptidase 33 [ Homo sapiens (human) ]

    Gene ID: 23032, updated on 28-Oct-2024

    Summary

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    Official Symbol
    USP33provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 33provided by HGNC
    Primary source
    HGNC:HGNC:20059
    See related
    Ensembl:ENSG00000077254 MIM:615146; AllianceGenome:HGNC:20059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VDU1
    Summary
    This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
    Expression
    Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See USP33 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (77695987..77759852, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (77534817..77598662, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78161672..78225537, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger ZZ-type containing 3 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:78127789-78128288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1002 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:78149296-78150069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:78241322-78241846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1221 Neighboring gene actin gamma 1 pseudogene 21 Neighboring gene RNA, 5S ribosomal pseudogene 21 Neighboring gene mitoguardin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma. Gan Q, et al. Life Sci, 2020 Nov 15. PMID 32835698
    2. Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries. Romanuik TL, et al. BMC Genomics, 2009 Oct 15. PMID 19832994, Free PMC Article
    3. Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma. Han PP, et al. J Neurosurg Sci, 2023 Feb. PMID 32972109
    4. Reduced Expression of Deubiquitinase USP33 Is Associated with Tumor Progression and Poor Prognosis of Gastric Adenocarcinoma. Chen Y, et al. Med Sci Monit, 2018 May 26. PMID 29802710, Free PMC Article
    5. USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration. Huang Z, et al. Int J Cancer, 2015 Apr 15. PMID 25242263, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells.
      Title: USP33 enhances cell survival and stemness by deubiquitinating CTNNB1 in BXPC-3 and SW1990 cells.
    2. Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma.
      Title: Downregulation of USP33 inhibits Slit/Robo signaling pathway and is associated with poor patient survival of glioma.
    3. USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells.
      Title: USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells.
    4. Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.
      Title: Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.
    5. Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.
      Title: Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.
    6. USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
      Title: USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy.
    7. SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia.
      Title: SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia.
    8. USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma.
      Title: USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma.
    9. Our study reveals the inhibitory function of Slit-Robo signalling in gastric cancer (GC) and uncovers a role of USP33 in suppressing cancer cell migration and epithelial-mesenchymal transition by enhancing Slit2-Robo1 signalling. USP33 represents a feasible choice as a prognostic biomarker for GC.
      Title: Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT.
    10. USP33 was downregulated in gastric adenocarcinoma.
      Title: Reduced Expression of Deubiquitinase USP33 Is Associated with Tumor Progression and Poor Prognosis of Gastric Adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1097, MGC16868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of VCB complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 33
    Names
    VHL-interacting deubiquitinating enzyme 1
    deubiquitinating enzyme 33
    pVHL-interacting deubiquitinating enzyme 1
    ubiquitin thioesterase 33
    ubiquitin thiolesterase 33
    ubiquitin-specific-processing protease 33
    NP_001364359.1
    NP_001364360.1
    NP_001364361.1
    NP_001364362.1
    NP_001364363.1
    NP_001364364.1
    NP_001364365.1
    NP_001364366.1
    NP_001364367.1
    NP_001364368.1
    NP_055832.3
    NP_963918.1
    NP_963920.1
    XP_011539358.1
    XP_047305687.1
    XP_047305691.1
    XP_054191234.1
    XP_054191235.1
    XP_054191236.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377430.1 → NP_001364359.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (4) summary
      smart00695
      Location:832 → 916
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:39 → 285
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:185 → 704
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl12116
      Location:726 → 795
      DUSP; DUSP domain

    2. NM_001377431.1 → NP_001364360.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (4) summary
      smart00695
      Location:801 → 885
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 254
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:154 → 673
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl12116
      Location:695 → 764
      DUSP; DUSP domain

    3. NM_001377432.1 → NP_001364361.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      COG5207
      Location:39 → 285
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:185 → 712
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl12116
      Location:734 → 803
      DUSP; DUSP domain

    4. NM_001377433.1 → NP_001364362.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      smart00695
      Location:741 → 825
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:39 → 285
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:185 → 671
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. NM_001377434.1 → NP_001364363.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      COG5207
      Location:8 → 254
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:154 → 681
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl12116
      Location:703 → 772
      DUSP; DUSP domain

    6. NM_001377435.1 → NP_001364364.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      smart00695
      Location:710 → 794
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 254
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:154 → 640
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. NM_001377436.1 → NP_001364365.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      COG5207
      Location:8 → 254
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:154 → 673
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl12116
      Location:695 → 764
      DUSP; DUSP domain

    8. NM_001377437.1 → NP_001364366.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      smart00695
      Location:702 → 786
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 254
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:154 → 632
      UCH; Ubiquitin carboxyl-terminal hydrolase

    9. NM_001377438.1 → NP_001364367.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      smart00695
      Location:661 → 745
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:294 → 534
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl12116
      Location:555 → 624
      DUSP; DUSP domain

    10. NM_001377439.1 → NP_001364368.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC114487
      Conserved Domains (3) summary
      smart00695
      Location:661 → 745
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:294 → 534
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl12116
      Location:555 → 624
      DUSP; DUSP domain

    11. NM_015017.5 → NP_055832.3  ubiquitin carboxyl-terminal hydrolase 33 isoform 1

      See identical proteins and their annotated locations for NP_055832.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF383172, AF383173, AI569971, BC016663
      Consensus CDS
      CCDS678.1
      UniProtKB/Swiss-Prot
      Q8TEY6, Q8TEY7, Q96AV6, Q9H9F0, Q9UPQ5
      Related
      ENSP00000359829.1, ENST00000370793.5
      Conserved Domains (6) summary
      smart00695
      Location:840 → 924
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:473 → 713
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:186 → 288
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:184 → 712
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:61 → 121
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:734 → 803
      DUSP; DUSP domain

    12. NM_201624.3 → NP_963918.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 2

      See identical proteins and their annotated locations for NP_963918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF383173, AI569971, BC016663
      Consensus CDS
      CCDS679.1
      UniProtKB/Swiss-Prot
      Q8TEY7
      Related
      ENSP00000359830.3, ENST00000370794.7
      Conserved Domains (6) summary
      smart00695
      Location:809 → 893
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:442 → 682
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:155 → 257
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:153 → 681
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:30 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      cl12116
      Location:703 → 772
      DUSP; DUSP domain

    13. NM_201626.3 → NP_963920.1  ubiquitin carboxyl-terminal hydrolase 33 isoform 3

      See identical proteins and their annotated locations for NP_963920.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region and differs in the 3' UTR compared to variant 1. The encoded isoform (3) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC114487, AF383172, BC016663
      Consensus CDS
      CCDS680.1
      UniProtKB/Swiss-Prot
      Q8TEY7
      Related
      ENSP00000359828.3, ENST00000370792.7
      Conserved Domains (3) summary
      pfam00443
      Location:185 → 704
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl02553
      Location:39 → 285
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl12116
      Location:726 → 795
      DUSP; DUSP domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      77695987..77759852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449735.1 → XP_047305691.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

    2. XM_047449731.1 → XP_047305687.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

    3. XM_011541056.3 → XP_011539358.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

      Conserved Domains (3) summary
      cd02257
      Location:461 → 595
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl02553
      Location:184 → 289
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:61 → 121
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      77534817..77598662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335260.1 → XP_054191235.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

    2. XM_054335259.1 → XP_054191234.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

    3. XM_054335261.1 → XP_054191236.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEY7.2 GenPept UniProtKB/Swiss-Prot:Q8TEY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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