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    TANGO2 transport and golgi organization 2 homolog [ Homo sapiens (human) ]

    Gene ID: 128989, updated on 28-Oct-2024

    Summary

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    Official Symbol
    TANGO2provided by HGNC
    Official Full Name
    transport and golgi organization 2 homologprovided by HGNC
    Primary source
    HGNC:HGNC:25439
    See related
    Ensembl:ENSG00000183597 MIM:616830; AllianceGenome:HGNC:25439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MECRCN; C22orf25
    Summary
    This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TANGO2 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (20017023..20067164)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (20394641..20444782)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20004546..20054687)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19951049-19951764 Neighboring gene microRNA 4761 Neighboring gene ARVCF delta catenin family member Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19970318-19971255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19971256-19972192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:19973130-19974065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13470 Neighboring gene uncharacterized LOC124905082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:19998201-19999025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20018676-20019372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18669 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:20026069-20026230 Neighboring gene microRNA 185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20045081-20045581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:20053631-20054131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18670 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:20070687-20071305 Neighboring gene DGCR8 microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene microRNA 1306

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TANGO2 Deficiency. Adam MP, et al. , 1993. PMID 29369572
    2. Defects in lipid homeostasis reflect the function of TANGO2 in phospholipid and neutral lipid metabolism. Lujan AL, et al. Elife, 2023 Mar 24. PMID 36961129, Free PMC Article
    3. Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease. Mehranfar M, et al. Biochem Biophys Res Commun, 2024 Jul 12. PMID 38718569
    4. Mitochondrial dysfunction associated with TANGO2 deficiency. Heiman P, et al. Sci Rep, 2022 Feb 23. PMID 35197517, Free PMC Article
    5. Variable clinical severity in TANGO2 deficiency: Case series and literature review. Schymick J, et al. Am J Med Genet A, 2022 Feb. PMID 34668327

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease.
      Title: Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease.
    2. Molecular insight into CREBBP and TANGO2 variants causing intellectual disability.
      Title: Molecular insight into CREBBP and TANGO2 variants causing intellectual disability.
    3. Variable clinical severity in TANGO2 deficiency: Case series and literature review.
      Title: Variable clinical severity in TANGO2 deficiency: Case series and literature review.
    4. Mitochondrial dysfunction associated with TANGO2 deficiency.
      Title: Mitochondrial dysfunction associated with TANGO2 deficiency.
    5. Clinical and biological characterization of 20 patients with TANGO2 deficiency indicates novel triggers of metabolic crises and no primary energetic defect.
      Title: Clinical and biological characterization of 20 patients with TANGO2 deficiency indicates novel triggers of metabolic crises and no primary energetic defect.
    6. The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.
      Title: The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.
    7. Clinical phenotype associated with TANGO2 gene mutation.
      Title: Clinical phenotype associated with TANGO2 gene mutation.
    8. Clinical presentation and proteomic signature of patients with TANGO2 mutations.
      Title: Clinical presentation and proteomic signature of patients with TANGO2 mutations.
    9. TANGO2 deficiency as a cause of neurodevelopmental delay with indirect effects on mitochondrial energy metabolism.
      Title: TANGO2 deficiency as a cause of neurodevelopmental delay with indirect effects on mitochondrial energy metabolism.
    10. Variants from the 14 patients described are shown above the gene depiction with red bars for deletions and lines for single nucleotide variants (SNV), and pathogenic variants from prior studies are shown below (light blue bars for deletions and lines for SNV) based on TANGO2 transcript NM152906.6 (2623 bp).
      Title: TANGO2: expanding the clinical phenotype and spectrum of pathogenic variants.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761P1121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046857.1 RefSeqGene

      Range
      9111..55165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001283106.3 → NP_001270035.1  transport and Golgi organization protein 2 homolog isoform a

      See identical proteins and their annotated locations for NP_001270035.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK289862, BC041339, DC303300, HY135099
      Consensus CDS
      CCDS13772.1
      UniProtKB/Swiss-Prot
      A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    2. NM_001283116.3 → NP_001270045.1  transport and Golgi organization protein 2 homolog isoform a

      See identical proteins and their annotated locations for NP_001270045.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, CF552364, DA176876
      Consensus CDS
      CCDS13772.1
      UniProtKB/Swiss-Prot
      A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    3. NM_001283129.3 → NP_001270058.1  transport and Golgi organization protein 2 homolog isoform b

      See identical proteins and their annotated locations for NP_001270058.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK316056, BC041339
      Consensus CDS
      CCDS63405.1
      UniProtKB/TrEMBL
      A8K1E7
      Related
      ENSP00000403645.2, ENST00000456048.5
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 300
      TANGO2; Transport and Golgi organization 2

    4. NM_001283148.3 → NP_001270077.1  transport and Golgi organization protein 2 homolog isoform c

      See identical proteins and their annotated locations for NP_001270077.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK316020, BC041339, DA176876
      UniProtKB/TrEMBL
      B7Z4V5, B7Z9Q5
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 201
      TANGO2; Transport and Golgi organization 2

    5. NM_001283154.3 → NP_001270083.1  transport and Golgi organization protein 2 homolog isoform c

      See identical proteins and their annotated locations for NP_001270083.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, BI544307, BU173566
      UniProtKB/TrEMBL
      B7Z4V5, B7Z9Q5
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 201
      TANGO2; Transport and Golgi organization 2

    6. NM_001283179.3 → NP_001270108.1  transport and Golgi organization protein 2 homolog isoform d

      See identical proteins and their annotated locations for NP_001270108.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, BX345246, DC303300, HY135099
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000385662.1, ENST00000401886.5
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 197
      TANGO2; Transport and Golgi organisation 2

    7. NM_001283186.3 → NP_001270115.1  transport and Golgi organization protein 2 homolog isoform d

      See identical proteins and their annotated locations for NP_001270115.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK092484, BC041339, DA176876
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000381122.2, ENST00000398042.6
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 197
      TANGO2; Transport and Golgi organisation 2

    8. NM_001283199.3 → NP_001270128.1  transport and Golgi organization protein 2 homolog isoform e

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, BI544307, BI911898
      Consensus CDS
      CCDS74821.1
      UniProtKB/TrEMBL
      A0A0A0MSI5
      Related
      ENSP00000389797.3, ENST00000447208.6
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 184
      TANGO2; Transport and Golgi organization 2

    9. NM_001283215.3 → NP_001270144.1  transport and Golgi organization protein 2 homolog isoform f

      See identical proteins and their annotated locations for NP_001270144.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK301366, AK316056, BC041339
      Consensus CDS
      CCDS63406.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000391262.2, ENST00000434570.6
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 192
      TANGO2; Transport and Golgi organization 2

    10. NM_001283235.3 → NP_001270164.1  transport and Golgi organization protein 2 homolog isoform g

      See identical proteins and their annotated locations for NP_001270164.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK298593, BC041339, DA176876
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000402926.2, ENST00000432883.5
      Conserved Domains (1) summary
      pfam05742
      Location:32 → 161
      TANGO2; Transport and Golgi organisation 2

    11. NM_001283248.3 → NP_001270177.1  transport and Golgi organization protein 2 homolog isoform h

      See identical proteins and their annotated locations for NP_001270177.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK297075, BC041339, DA176876
      Consensus CDS
      CCDS74822.1
      UniProtKB/TrEMBL
      B7Z4A5, C9JKN2
      Related
      ENSP00000396182.3, ENST00000420290.6
      Conserved Domains (1) summary
      cl01315
      Location:1 → 89
      TANGO2; Transport and Golgi organization 2

    12. NM_001322141.2 → NP_001309070.1  transport and Golgi organization protein 2 homolog isoform i

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BG685068, BP193987
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 352
      TANGO2; Transport and Golgi organization 2

    13. NM_001322142.2 → NP_001309071.1  transport and Golgi organization protein 2 homolog isoform j

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 311
      TANGO2; Transport and Golgi organization 2

    14. NM_001322143.2 → NP_001309072.1  transport and Golgi organization protein 2 homolog isoform b

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, AL713640, BM013784, DB021425
      Consensus CDS
      CCDS63405.1
      UniProtKB/TrEMBL
      A8K1E7
      Related
      ENSP00000384827.1, ENST00000401833.5
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 300
      TANGO2; Transport and Golgi organization 2

    15. NM_001322144.2 → NP_001309073.1  transport and Golgi organization protein 2 homolog isoform l

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      UniProtKB/TrEMBL
      B7Z4V5
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 242
      TANGO2; Transport and Golgi organization 2

    16. NM_001322145.2 → NP_001309074.1  transport and Golgi organization protein 2 homolog isoform m

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 238
      TANGO2; Transport and Golgi organization 2

    17. NM_001322146.2 → NP_001309075.1  transport and Golgi organization protein 2 homolog isoform k

      Status: REVIEWED

      Source sequence(s)
      AA319727, AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:55 → 277
      TANGO2; Transport and Golgi organization 2

    18. NM_001322147.2 → NP_001309076.1  transport and Golgi organization protein 2 homolog isoform m

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 238
      TANGO2; Transport and Golgi organization 2

    19. NM_001322148.2 → NP_001309077.1  transport and Golgi organization protein 2 homolog isoform n

      Status: REVIEWED

      Source sequence(s)
      AC006547, AK316056, BM048105
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:55 → 225
      TANGO2; Transport and Golgi organisation 2

    20. NM_001322149.2 → NP_001309078.1  transport and Golgi organization protein 2 homolog isoform r

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BI911898, DC349456
      Conserved Domains (1) summary
      pfam05742
      Location:60 → 225
      TANGO2; Transport and Golgi organization 2

    21. NM_001322150.2 → NP_001309079.1  transport and Golgi organization protein 2 homolog isoform o

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BP193987
      Conserved Domains (1) summary
      cl01315
      Location:32 → 213
      TANGO2; Transport and Golgi organization 2

    22. NM_001322153.2 → NP_001309082.1  transport and Golgi organization protein 2 homolog isoform o

      Status: REVIEWED

      Source sequence(s)
      AC006547, DC301369, DC315148
      Conserved Domains (1) summary
      cl01315
      Location:32 → 213
      TANGO2; Transport and Golgi organization 2

    23. NM_001322155.2 → NP_001309084.1  transport and Golgi organization protein 2 homolog isoform o

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      cl01315
      Location:32 → 213
      TANGO2; Transport and Golgi organization 2

    24. NM_001322160.2 → NP_001309089.1  transport and Golgi organization protein 2 homolog isoform p

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      cl01315
      Location:55 → 167
      TANGO2; Transport and Golgi organization 2

    25. NM_001322163.2 → NP_001309092.1  transport and Golgi organization protein 2 homolog isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 197
      TANGO2; Transport and Golgi organisation 2

    26. NM_001322166.2 → NP_001309095.1  transport and Golgi organization protein 2 homolog isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 197
      TANGO2; Transport and Golgi organisation 2

    27. NM_001322167.2 → NP_001309096.1  transport and Golgi organization protein 2 homolog isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 197
      TANGO2; Transport and Golgi organisation 2

    28. NM_001322169.2 → NP_001309098.1  transport and Golgi organization protein 2 homolog isoform q

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 139
      TANGO2; Transport and Golgi organization 2

    29. NM_001322171.2 → NP_001309100.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BF726547, CD675132
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:32 → 161
      TANGO2; Transport and Golgi organisation 2

    30. NM_001322172.2 → NP_001309101.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BF726547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:32 → 161
      TANGO2; Transport and Golgi organisation 2

    31. NM_001322173.2 → NP_001309102.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:32 → 161
      TANGO2; Transport and Golgi organisation 2

    32. NM_001322174.2 → NP_001309103.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:32 → 161
      TANGO2; Transport and Golgi organisation 2

    33. NM_001322175.2 → NP_001309104.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:32 → 161
      TANGO2; Transport and Golgi organisation 2

    34. NM_152906.7 → NP_690870.3  transport and Golgi organization protein 2 homolog isoform a

      See identical proteins and their annotated locations for NP_690870.3

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK297922, BC041339
      Consensus CDS
      CCDS13772.1
      UniProtKB/Swiss-Prot
      A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16
      UniProtKB/TrEMBL
      A8K1E7
      Related
      ENSP00000332721.4, ENST00000327374.9
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    RNA

    1. NR_104274.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK301054, BC041339

    2. NR_104275.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547

    3. NR_136206.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547

    4. NR_136211.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006547, BI544307, BP303570

    5. NR_136212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      20017023..20067164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028580.2 → XP_016884069.1  transport and Golgi organization protein 2 homolog isoform X2

      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 311
      TANGO2; Transport and Golgi organization 2

    2. XM_047441121.1 → XP_047297077.1  transport and Golgi organization protein 2 homolog isoform X3

    3. XM_017028579.2 → XP_016884068.1  transport and Golgi organization protein 2 homolog isoform X2

      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 311
      TANGO2; Transport and Golgi organization 2

    4. XM_047441124.1 → XP_047297080.1  transport and Golgi organization protein 2 homolog isoform X6

      UniProtKB/Swiss-Prot
      A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16

    5. XM_047441118.1 → XP_047297074.1  transport and Golgi organization protein 2 homolog isoform X1

    6. XM_047441131.1 → XP_047297087.1  transport and Golgi organization protein 2 homolog isoform X12

    7. XM_047441119.1 → XP_047297075.1  transport and Golgi organization protein 2 homolog isoform X3

    8. XM_017028577.2 → XP_016884066.1  transport and Golgi organization protein 2 homolog isoform X2

      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 311
      TANGO2; Transport and Golgi organization 2

    9. XM_017028585.2 → XP_016884074.1  transport and Golgi organization protein 2 homolog isoform X7

    10. XM_047441123.1 → XP_047297079.1  transport and Golgi organization protein 2 homolog isoform X5

    11. XM_047441130.1 → XP_047297086.1  transport and Golgi organization protein 2 homolog isoform X11

    12. XM_047441125.1 → XP_047297081.1  transport and Golgi organization protein 2 homolog isoform X8

    13. XM_047441126.1 → XP_047297082.1  transport and Golgi organization protein 2 homolog isoform X8

    14. XM_047441128.1 → XP_047297084.1  transport and Golgi organization protein 2 homolog isoform X9

    15. XM_047441127.1 → XP_047297083.1  transport and Golgi organization protein 2 homolog isoform X8

    16. XM_047441129.1 → XP_047297085.1  transport and Golgi organization protein 2 homolog isoform X10

    17. XM_047441122.1 → XP_047297078.1  transport and Golgi organization protein 2 homolog isoform X4

    18. XM_047441120.1 → XP_047297076.1  transport and Golgi organization protein 2 homolog isoform X3

    19. XM_047441132.1 → XP_047297088.1  transport and Golgi organization protein 2 homolog isoform X13

      UniProtKB/TrEMBL
      A0A0A0MSI5

    20. XM_017028586.2 → XP_016884075.1  transport and Golgi organization protein 2 homolog isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      20394641..20444782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325065.1 → XP_054181040.1  transport and Golgi organization protein 2 homolog isoform X2

    2. XM_054325069.1 → XP_054181044.1  transport and Golgi organization protein 2 homolog isoform X3

    3. XM_054325066.1 → XP_054181041.1  transport and Golgi organization protein 2 homolog isoform X2

    4. XM_054325072.1 → XP_054181047.1  transport and Golgi organization protein 2 homolog isoform X6

      UniProtKB/Swiss-Prot
      A8MUE9, B7WNV6, B7Z583, B7Z730, D3DX23, Q6ICL3, Q8IW05, Q8NAL0, Q8TCS0, Q96M16

    5. XM_054325063.1 → XP_054181038.1  transport and Golgi organization protein 2 homolog isoform X1

    6. XM_054325081.1 → XP_054181056.1  transport and Golgi organization protein 2 homolog isoform X12

    7. XM_054325068.1 → XP_054181043.1  transport and Golgi organization protein 2 homolog isoform X3

    8. XM_054325064.1 → XP_054181039.1  transport and Golgi organization protein 2 homolog isoform X2

    9. XM_054325074.1 → XP_054181049.1  transport and Golgi organization protein 2 homolog isoform X7

    10. XM_054325067.1 → XP_054181042.1  transport and Golgi organization protein 2 homolog isoform X3

    11. XM_054325082.1 → XP_054181057.1  transport and Golgi organization protein 2 homolog isoform X13

      UniProtKB/TrEMBL
      A0A0A0MSI5

    12. XM_054325073.1 → XP_054181048.1  transport and Golgi organization protein 2 homolog isoform X7

    13. XM_054325070.1 → XP_054181045.1  transport and Golgi organization protein 2 homolog isoform X4

    14. XM_054325071.1 → XP_054181046.1  transport and Golgi organization protein 2 homolog isoform X5

    15. XM_054325080.1 → XP_054181055.1  transport and Golgi organization protein 2 homolog isoform X11

    16. XM_054325075.1 → XP_054181050.1  transport and Golgi organization protein 2 homolog isoform X8

    17. XM_054325076.1 → XP_054181051.1  transport and Golgi organization protein 2 homolog isoform X8

    18. XM_054325078.1 → XP_054181053.1  transport and Golgi organization protein 2 homolog isoform X9

    19. XM_054325077.1 → XP_054181052.1  transport and Golgi organization protein 2 homolog isoform X8

    20. XM_054325084.1 → XP_054181059.1  transport and Golgi organization protein 2 homolog isoform X14

      UniProtKB/TrEMBL
      A8MWT1

    21. XM_054325079.1 → XP_054181054.1  transport and Golgi organization protein 2 homolog isoform X10

    22. XM_054325083.1 → XP_054181058.1  transport and Golgi organization protein 2 homolog isoform X14

      UniProtKB/TrEMBL
      A8MWT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ICL3.1 GenPept UniProtKB/Swiss-Prot:Q6ICL3

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