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    COP9 COP9 signalosome, subunit CSN8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827049, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COP9
    Official Full Name
    COP9 signalosome, subunit CSN8
    Primary source
    TAIR:AT4G14110
    Locus tag
    AT4G14110
    See related
    Araport:AT4G14110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CONSTITUTIVE PHOTOMORPHOGENIC 9; COP9 SIGNALOSOME SUBUNIT 8; CSN8; DL3095C; EMB143; EMBRYO DEFECTIVE 143; FCAALL.131; FUS7; FUSCA 7; FUSCA PROTEIN FUS7
    Summary
    Represses photomorphogenesis and induces skotomorphogenesis in the dark. A component of the COP9 signalosome complex.
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    Genomic context

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    See COP9 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (8132880..8134988, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene F-box/RNI-like superfamily protein Neighboring gene capsid-like protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene xyloglucan endotransglucosylase/hydrolase 15 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The COP9 SIGNALOSOME Is Required for Postembryonic Meristem Maintenance in Arabidopsis thaliana. Franciosini A, et al. Mol Plant, 2015 Nov 2. PMID 26277260
    2. Many jobs for one good cop - the COP9 signalosome guards development and defense. Stratmann JW, et al. Plant Sci, 2012 Apr. PMID 22325866
    3. COP9: a new genetic locus involved in light-regulated development and gene expression in arabidopsis. Wei N, et al. Plant Cell, 1992 Dec. PMID 1467650, Free PMC Article
    4. COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis. Stuttmann J, et al. J Biol Chem, 2009 Mar 20. PMID 19147500, Free PMC Article
    5. The eer5 mutation, which affects a novel proteasome-related subunit, indicates a prominent role for the COP9 signalosome in resetting the ethylene-signaling pathway in Arabidopsis. Christians MJ, et al. Plant J, 2008 Aug. PMID 18429939

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. while constitutively photomorphogenic9 (COP9) signalosome (CSN) mutants can complete embryogenesis and are able to germinate, they progressively lose meristem activity upon germination until they become unable to sustain growth
      Title: The COP9 SIGNALOSOME Is Required for Postembryonic Meristem Maintenance in Arabidopsis thaliana.
    2. This review provides an overview of the highly complex regulation of CULLIN-RING E3 ubiquitin ligase activity by COP9 signalosome (CSN), and the many roles of the CSN in plant development and defense.
      Title: Many jobs for one good cop - the COP9 signalosome guards development and defense.
    3. SMAP1 interacts with the COP9 signalosome.
      Title: SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis.
    4. COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis
      Title: COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis.
    5. COP9 has a role in ethylene signaling.
      Title: The eer5 mutation, which affects a novel proteasome-related subunit, indicates a prominent role for the COP9 signalosome in resetting the ethylene-signaling pathway in Arabidopsis.
    6. study concludes that the COP9 signalosome maintains a precise regulation of eIF3e levels, which is necessary for normal development in Arabidopsis
      Title: Arabidopsis eIF3e is regulated by the COP9 signalosome and has an impact on development and protein translation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117488.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COP9 signalosome, subunit CSN8
    NP_193147.1
    • CONSTITUTIVE PHOTOMORPHOGENIC 9 (COP9); CONTAINS InterPro DOMAIN/s: COP9 signalosome, subunit CSN8 (InterPro:IPR019280); Has 218 Blast hits to 218 proteins in 91 species: Archae - 0; Bacteria - 0; Metazoa - 136; Fungi - 17; Plants - 54; Viruses - 0; Other Eukaryotes - 11 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8132880..8134988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117488.4 → NP_193147.1  COP9 signalosome, subunit CSN8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43255, Q8GWZ4
      UniProtKB/TrEMBL
      A0A5S9XSU9, A0A654FP31, Q548D1
      Conserved Domains (1) summary
      pfam10075
      Location:36 → 171
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43255.1

    Gene LinkOut

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