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    Hbbl1 hemoglobin subunit beta like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100134871, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Hbbl1provided by RGD
    Official Full Name
    hemoglobin subunit beta like 1provided by RGD
    Primary source
    RGD:2290038
    See related
    AllianceGenome:RGD:2290038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cellular oxidant detoxification and oxygen transport. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 187243.0), Lung (RPKM 41900.0) and 1 other tissue See more
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    Genomic context

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    See Hbbl1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (167648859..167650235, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (158236972..158238348, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (168957460..168958836)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hemoglobin, beta adult s chain Neighboring gene hemoglobin, beta adult major chain Neighboring gene hemoglobin, beta adult minor chain Neighboring gene hemoglobin subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic sequence of a Sprague-Dawley rat beta-globin gene. Wong WM, et al. Nucleic Acids Res, 1988 Mar 25. PMID 3357786, Free PMC Article
    2. Sequence of the rat beta-globin mRNA. Ohshita Y, et al. Nucleic Acids Res, 1987 Feb 11. PMID 3453111, Free PMC Article
    3. Genomic sequence of rat beta-globin minor gene. Stevanović M, et al. Nucleic Acids Res, 1989 Jun 26. PMID 2748344, Free PMC Article
    4. cDNA sequences of two beta-globin genes in a Sprague-Dawley rat. Woo C, et al. Nucleic Acids Res, 1989 Nov 11. PMID 2587229, Free PMC Article
    5. Origin of rat beta-globin haplotypes containing three and five genes. Paunesku T, et al. Mol Biol Evol, 1990 Sep. PMID 2263193

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbon dioxide transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxygen transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxygen transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of hemoglobin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    hemoglobin subunit beta-2
    Names
    III beta-2 globin
    beta globin minor
    beta-2-globin
    beta-min-globin chain
    hemoglobin beta chain, minor-form
    hemoglobin beta-2 chain
    three beta-2 globin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113223.2 → NP_001106694.1  hemoglobin subunit beta-2

      See identical proteins and their annotated locations for NP_001106694.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P11517
      UniProtKB/TrEMBL
      A0A0G2JTW9, A0A1K0FUA6, A0A1K0GGD1
      Conserved Domains (1) summary
      cd08925
      Location:8 → 146
      Hb-beta-like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      167648859..167650235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11517.2 GenPept UniProtKB/Swiss-Prot:P11517

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.