Inhbe inhibin subunit beta E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inhbeprovided by RGD
Official Full Name: inhibin subunit beta Eprovided by RGD
Primary source: RGD:621196
See related: EnsemblRapid:ENSRNOG00000007601 AllianceGenome:RGD:621196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity. Predicted to be involved in SMAD protein signal transduction and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human INHBE (inhibin subunit beta E). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 346.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65061531..65064519, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63176221..63179209, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70641423..70642848, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

first report of a biological activity of activin C and E supports an involvement in liver tissue homeostasis
Title: Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells.
Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.
Title: Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.
Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours
Title: Deregulation of the activin/follistatin system in hepatocarcinogenesis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inhibin beta E chain

Names: activin beta E; activin beta-E chain; inhibin beta E subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031815.3 → NP_114003.2 inhibin beta E chain precursor

See identical proteins and their annotated locations for NP_114003.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O88959, Q9R285

UniProtKB/TrEMBL

A0A0G2JSJ0, A6HQV3

Related

ENSRNOP00000010106.2, ENSRNOT00000010106.6

Conserved Domains (1) summary

cd19406
Location:247 → 350

TGF_beta_INHBC_E; transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins