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    TLE2 TLE family member 2, transcriptional corepressor [ Homo sapiens (human) ]

    Gene ID: 7089, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TLE2provided by HGNC
    Official Full Name
    TLE family member 2, transcriptional corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:11838
    See related
    Ensembl:ENSG00000065717 MIM:601041; AllianceGenome:HGNC:11838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG; ESG2; GRG2
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Located in focal adhesion and nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in salivary gland (RPKM 17.9), fat (RPKM 13.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TLE2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2997644..3047635, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2971143..3021120, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2997642..3047633, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13722 Neighboring gene zinc finger protein 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982456-2982974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982975-2983491 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:2984010-2984526 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3003179-3003325 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3006113-3007047 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3007156-3007353 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9821 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3041680-3041803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:3054606-3055171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3057431-3057995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3057996-3058560 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3059514-3059717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9824 Neighboring gene uncharacterized LOC105372242 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3066867-3067075 Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene Sharpr-MPRA regulatory region 11171

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. Javed A, et al. J Cell Sci, 2000 Jun. PMID 10825294
    2. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. Liu Y, et al. Genomics, 1996 Jan 1. PMID 8808280
    3. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. He Z, et al. J Virol, 2010 Feb. PMID 19939918, Free PMC Article
    4. PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Ren B, et al. Genes Dev, 1999 Jan 1. PMID 9887105, Free PMC Article
    5. The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. Palaparti A, et al. J Biol Chem, 1997 Oct 17. PMID 9334241

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Immunofluorescence analysis showed that TLE2 and RTA were colocalized in the same nuclear compartment in KSHV-infected cells.
      Title: Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41188

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 2
    Names
    enhancer of split groucho-like protein 2
    transducin like enhancer of split 2
    transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    transducin-like enhancer of split 2, homolog of Drosophila E(sp1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144761.2 → NP_001138233.1  transducin-like enhancer protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences compared to variant 4, one of which results in a frameshift. This results in a shorter isoform (2) with distinct N- and C-termini compared to isoform 4.
      Source sequence(s)
      AK308137, BC017364
      Consensus CDS
      CCDS45913.1
      UniProtKB/Swiss-Prot
      Q04725
      Related
      ENSP00000468279.1, ENST00000591529.5
      Conserved Domains (4) summary
      COG2319
      Location:469 → 693
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:18 → 141
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:474 → 513
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:463 → 631
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001144762.2 → NP_001138234.1  transducin-like enhancer protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences compared to variant 4. This results in a shorter isoform (2) with a shorter N-terminus compared to isoform 4.
      Source sequence(s)
      AC011549, AK293407, BC017364
      Consensus CDS
      CCDS45912.1
      UniProtKB/Swiss-Prot
      Q04725
      Related
      ENSP00000392427.2, ENST00000443826.7
      Conserved Domains (4) summary
      COG2319
      Location:333 → 619
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 68
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:338 → 377
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:334 → 618
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001300846.2 → NP_001287775.1  transducin-like enhancer protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC011549, AK312285, BC017364, HY046309, HY140405
      Consensus CDS
      CCDS74255.1
      UniProtKB/TrEMBL
      K7EMK7
      Related
      ENSP00000466542.1, ENST00000590536.5
      Conserved Domains (4) summary
      COG2319
      Location:456 → 742
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:461 → 500
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:457 → 741
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_003260.5 → NP_003251.2  transducin-like enhancer protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003251.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 4. It encodes isoform 1, which is shorter by an amino acid, compared to isoform 4.
      Source sequence(s)
      AC011549, AW262763, BC017364
      Consensus CDS
      CCDS45911.1
      UniProtKB/Swiss-Prot
      B4DE03, E9PEV7, F8WCH2, Q04725, Q8WVY0, Q9Y6S0
      Related
      ENSP00000262953.5, ENST00000262953.11
      Conserved Domains (4) summary
      sd00039
      Location:460 → 499
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl25539
      Location:456 → 740
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl26464
      Location:126 → 366
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      2997644..3047635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528230.2 → XP_011526532.1  transducin-like enhancer protein 2 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:444 → 730
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:449 → 488
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:445 → 729
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006722864.3 → XP_006722927.1  transducin-like enhancer protein 2 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:456 → 680
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:461 → 500
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:450 → 618
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      2971143..3021120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321901.1 → XP_054177876.1  transducin-like enhancer protein 2 isoform X1

    2. XM_054321902.1 → XP_054177877.1  transducin-like enhancer protein 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04725.2 GenPept UniProtKB/Swiss-Prot:Q04725

    Gene LinkOut

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