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    GPR19 G protein-coupled receptor 19 [ Homo sapiens (human) ]

    Gene ID: 2842, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GPR19provided by HGNC
    Official Full Name
    G protein-coupled receptor 19provided by HGNC
    Primary source
    HGNC:HGNC:4473
    See related
    Ensembl:ENSG00000183150 MIM:602927; AllianceGenome:HGNC:4473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cilium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    See GPR19 in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12660890..12717246, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12533185..12589333, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12813824..12849117, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 136 Neighboring gene cAMP responsive element binding protein like 2 Neighboring gene Sharpr-MPRA regulatory region 2795 Neighboring gene uncharacterized LOC124902880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:12796246-12797445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6018 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:12829332-12830160 Neighboring gene MPRA-validated peak1575 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6027 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12870680-12870868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6029 Neighboring gene uncharacterized LOC105369663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4265 Neighboring gene cyclin dependent kinase inhibitor 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues. Gerlach L, et al. Sci Rep, 2023 Nov 3. PMID 37923782, Free PMC Article
    2. GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process. Maudsley S, et al. Int J Mol Sci, 2023 May 9. PMID 37239845, Free PMC Article
    3. G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells. Rao A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Jul. PMID 28476646
    4. Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression. Kastner S, et al. Mol Cancer Res, 2012 Oct. PMID 22912338
    5. Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells. Montpetit A, et al. Hum Genet, 1999 Jul-Aug. PMID 10480372

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
      Title: Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues.
    2. GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process.
      Title: GPR19 Coordinates Multiple Molecular Aspects of Stress Responses Associated with the Aging Process.
    3. GPR19 overexpression drives MDA-MB-231 cells towards an epithelial phenotype. GPR19 upregulates E-cadherin via MAPK/ERK1/2 pathway.
      Title: G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells.
    4. G protein-coupled receptor 19 (GPR19) was found frequently overexpressed in tissue samples obtained from patients with small cell lung cancer.
      Title: Expression of G protein-coupled receptor 19 in human lung cancer cells is triggered by entry into S-phase and supports G(2)-M cell-cycle progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 19
    Names
    GPR-NGA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006143.3 → NP_006134.2  probable G-protein coupled receptor 19

      Status: VALIDATED

      Source sequence(s)
      AC008115
      Consensus CDS
      CCDS8652.1
      UniProtKB/Swiss-Prot
      Q15760
      UniProtKB/TrEMBL
      B9EK41
      Related
      ENSP00000498976.1, ENST00000651487.1
      Conserved Domains (1) summary
      cd15008
      Location:67 → 341
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12660890..12717246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428742.1 → XP_047284698.1  probable G-protein coupled receptor 19 isoform X2

      UniProtKB/Swiss-Prot
      Q15760

    2. XM_011520623.4 → XP_011518925.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_011518925.1

      UniProtKB/TrEMBL
      B9EK41
      Conserved Domains (2) summary
      pfam00001
      Location:101 → 349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91 → 277
      7tm_4; Olfactory receptor

    3. XM_011520624.3 → XP_011518926.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_011518926.1

      UniProtKB/TrEMBL
      B9EK41
      Conserved Domains (2) summary
      pfam00001
      Location:101 → 349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91 → 277
      7tm_4; Olfactory receptor

    4. XM_047428741.1 → XP_047284697.1  probable G-protein coupled receptor 19 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12533185..12589333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371850.1 → XP_054227825.1  probable G-protein coupled receptor 19 isoform X1

    2. XM_054371851.1 → XP_054227826.1  probable G-protein coupled receptor 19 isoform X1

    3. XM_054371849.1 → XP_054227824.1  probable G-protein coupled receptor 19 isoform X1

    4. XM_054371852.1 → XP_054227827.1  probable G-protein coupled receptor 19 isoform X2

      UniProtKB/TrEMBL
      Q6IBH2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15760.2 GenPept UniProtKB/Swiss-Prot:Q15760

    Gene LinkOut

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