BNA6 nicotinate-nucleotide diphosphorylase (carboxylating) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BNA6
Official Full Name: nicotinate-nucleotide diphosphorylase (carboxylating)
Primary source: SGD:S000001943
Locus tag: YFR047C
See related: AllianceGenome:SGD:S000001943; FungiDB:YFR047C; VEuPathDB:YFR047C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: QPT1
Summary: Enables nicotinate-nucleotide diphosphorylase (carboxylating) activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in cytoplasm and nucleus. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BNA6 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (244279..245166, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results allow insight into the kinetic mechanism of QAPRTase and provide an understanding of structural diversity in the active site of the Saccharomyces cerevisiae enzyme when compared to prokaryotic homologues
Title: Comprehensive X-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA Inferred from Electronic Annotation more info
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in quinolinate catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nicotinate-nucleotide diphosphorylase (carboxylating)

NP_602317.3

EC 2.4.2.19

Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

244279..245166 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180012.3 → NP_602317.3 TPA: nicotinate-nucleotide diphosphorylase (carboxylating) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_602317.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTT0, P43619

UniProtKB/TrEMBL

A7A287, B5VI72, C7GYF0, G2WDI8, N1P302

Conserved Domains (1) summary

TIGR00078
Location:17 → 293

nadC; nicotinate-nucleotide pyrophosphorylase