SCT1 bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SCT1
Official Full Name: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
Primary source: SGD:S000000107
Locus tag: YBL011W
See related: AllianceGenome:SGD:S000000107; FungiDB:YBL011W; VEuPathDB:YBL011W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAT2
Summary: Enables glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Involved in phospholipid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See SCT1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (203538..205817)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

novel mechanism for the regulation of fatty acid desaturation that is based on competition between Ole1p and the glycerol-3-phosphate acyltransferase Sct1p/Gat2p for the common substrate C16:0-CoA
Title: The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p.
Gat1 and Gat2 localized to both perinuclear and cortical endoplasmic reticula in actively proliferating cells.
Title: Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerone-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerone-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerone-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1

NP_009542.1

EC 2.3.1.15

EC 2.3.1.42

Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

203538..205817

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178251.1 → NP_009542.1 TPA: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPY8, P32784, Q07062, Q96TV1

UniProtKB/TrEMBL

G2W8Z7

Conserved Domains (2) summary

cd07992
Location:56 → 343

LPLAT_AAK14816-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like

pfam17158
Location:441 → 548

MASE4; Membrane-associated sensor, integral membrane domain