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    FMT1 methionyl-tRNA formyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852270, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FMT1
    Official Full Name
    methionyl-tRNA formyltransferase
    Primary source
    SGD:S000000109
    Locus tag
    YBL013W
    See related
    AllianceGenome:SGD:S000000109; FungiDB:YBL013W; VEuPathDB:YBL013W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables methionyl-tRNA formyltransferase activity. Involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FMT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (202056..203261)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene Rrn6p Neighboring gene bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 Neighboring gene Laa2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: gene disruption and tRNA substrate specificity. Vial L, et al. Biochemistry, 2003 Feb 4. PMID 12549912
    2. Isolation of Saccharomyces cerevisiae mitochondrial formyltetrahydrofolic acid:methionyl-tRNA transformylase and the hybridization of mitochondrial fMet-tRNA with mitochondrial DNA. Halbreich A, et al. Proc Natl Acad Sci U S A, 1971 Feb. PMID 5277072, Free PMC Article
    3. Mammalian mitochondrial initiation factor 2 supports yeast mitochondrial translation without formylated initiator tRNA. Tibbetts AS, et al. J Biol Chem, 2003 Aug 22. PMID 12799364
    4. Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. Li Y, et al. J Bacteriol, 2000 May. PMID 10781559, Free PMC Article
    5. Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNA(fMet). Franco LVR, et al. FEBS J, 2019 Apr. PMID 30767393

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methionyl-tRNA formyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionyl-tRNA formyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methionyl-tRNA formyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methionyl-tRNA formyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methionyl-tRNA formyltransferase
    NP_009540.2
    • Methionyl-tRNA formyltransferase; catalyzes formylation of mitochondria initiator Met-tRNA and residual cytosolic Met-tRNA due to inefficient translocation into the mitochondrial matrix; starvation or stationary phase entry increases Gcn2p phosphorylation-mediated cytosolic retention of Fmt1p, enhancing N-terminal protein formylation and ultimately N-end rule pathway mediated destruction that involves the Psh1p ubiquitin ligase; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      202056..203261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178253.1 → NP_009540.2  TPA: methionyl-tRNA formyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009540.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPY7, P32785, Q6RUA6
      UniProtKB/TrEMBL
      G2W8Z6, N1P909
      Conserved Domains (1) summary
      TIGR00460
      Location:30 → 393
      fmt; methionyl-tRNA formyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32785.2

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