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    P2RY4 pyrimidinergic receptor P2Y4 [ Homo sapiens (human) ]

    Gene ID: 5030, updated on 28-Oct-2024

    Summary

    Official Symbol
    P2RY4provided by HGNC
    Official Full Name
    pyrimidinergic receptor P2Y4provided by HGNC
    Primary source
    HGNC:HGNC:8542
    See related
    Ensembl:ENSG00000186912 MIM:300038; AllianceGenome:HGNC:8542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRU; P2P; UNR; P2Y4
    Summary
    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See P2RY4 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70258166..70260204, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68691490..68693528, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69478016..69480054, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene acyl-CoA wax alcohol acyltransferase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:69473037-69474236 Neighboring gene RNA, 5S ribosomal pseudogene 507 Neighboring gene Sharpr-MPRA regulatory region 5483 Neighboring gene arrestin 3 Neighboring gene RAB41, member RAS oncogene family

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled UTP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled UTP receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables G protein-coupled purinergic nucleotide receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    P2Y purinoceptor 4
    Names
    pyrimidinergic receptor P2Y, G-protein coupled, 4
    uridine nucleotide receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013250.1 RefSeqGene

      Range
      4601..6639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002565.4NP_002556.1  P2Y purinoceptor 4

      See identical proteins and their annotated locations for NP_002556.1

      Status: REVIEWED

      Source sequence(s)
      AL357752
      Consensus CDS
      CCDS14398.1
      UniProtKB/Swiss-Prot
      P51582, Q4VBB7, Q4VBB8, Q502W2, Q5JT22
      Related
      ENSP00000363643.2, ENST00000374519.4
      Conserved Domains (1) summary
      cd15374
      Location:36317
      7tmA_P2Y4; P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      70258166..70260204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      68691490..68693528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)