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    NTH2 alpha,alpha-trehalase NTH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852286, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NTH2
    Official Full Name
    alpha,alpha-trehalase NTH2
    Primary source
    SGD:S000000205
    Locus tag
    YBR001C
    See related
    AllianceGenome:SGD:S000000205; FungiDB:YBR001C; VEuPathDB:YBR001C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha,alpha-trehalase activity. Involved in trehalose catabolic process. Located in mitochondrion. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NTH2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (238941..241283, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene histone H2B Neighboring gene Ecm15p Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase Neighboring gene trans-hexaprenyltranstransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4. Wolfe KH, et al. Yeast, 1994 Apr. PMID 8091860
    2. Coupling High-Throughput and Targeted Screening for Identification of Nonobvious Metabolic Engineering Targets. Babaei M, et al. ACS Synth Biol, 2024 Jan 19. PMID 38141039, Free PMC Article
    3. Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. Nwaka S, et al. J Biol Chem, 1995 Apr 28. PMID 7730323
    4. Phenotypic features of trehalase mutants in Saccharomyces cerevisiae. Nwaka S, et al. FEBS Lett, 1995 Mar 6. PMID 7883049
    5. Evaluating cellular roles and phenotypes associated with trehalose degradation genes in Saccharomyces cerevisiae. Chen A, et al. G3 (Bethesda), 2024 Nov 6. PMID 39250759, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The behaviour of trehalase mutant strains demonstrates the participation of trehalases Nth1p, Nth2p and Ath1p in the mobilization of intracellular trehalose during growth recovery after saline stress.
      Title: The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.
    2. In this work, we showed that NTH2, a paralog of NTH1, encodes a functional trehalase that is implicated in trehalose mobilization.
      Title: New insights into trehalose metabolism by Saccharomyces cerevisiae: NTH2 encodes a functional cytosolic trehalase, and deletion of TPS1 reveals Ath1p-dependent trehalose mobilization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha,alpha-trehalase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha,alpha-trehalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha,alpha-trehalase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in trehalose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    alpha,alpha-trehalase NTH2
    NP_009555.1
    • Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      238941..241283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178349.1 → NP_009555.1  TPA: alpha,alpha-trehalase NTH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ02, P35172
      UniProtKB/TrEMBL
      G2W909
      Conserved Domains (1) summary
      COG1626
      Location:117 → 755
      TreA; Neutral trehalase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35172.1

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