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    ATF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854559, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ATF1
    Primary source
    FungiDB:YOR377W
    Locus tag
    YOR377W
    See related
    SGD:S000005904; AllianceGenome:SGD:S000005904; VEuPathDB:YOR377W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol O-acetyltransferase activity. Involved in acetate ester metabolic process involved in fermentation. Located in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1046226..1047803)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Amf1p Neighboring gene Rdr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased Acetate Ester Production of Polyploid Industrial Brewer's Yeast Strains via Precise and Seamless "Self-cloning" Integration Strategy. Dong J, et al. Iran J Biotechnol, 2019 Apr. PMID 31457054, Free PMC Article
    2. Improving the Organoleptic Properties of a Craft Mezcal Beverage by Increasing Fatty Acid Ethyl Ester Contents through ATF1 Expression in an Engineered Kluyveromyces marxianus UMPe-1 Yeast. Campos-García J, et al. J Agric Food Chem, 2018 May 2. PMID 29644852
    3. Saccharomyces cerevisiae Atf1p is an alcohol acetyltransferase and a thioesterase in vitro. Nancolas B, et al. Yeast, 2017 Jun. PMID 28160314, Free PMC Article
    4. The fungal aroma gene ATF1 promotes dispersal of yeast cells through insect vectors. Christiaens JF, et al. Cell Rep, 2014 Oct 23. PMID 25310977
    5. Production of the aroma chemicals 3-(methylthio)-1-propanol and 3-(methylthio)-propylacetate with yeasts. Etschmann MM, et al. Appl Microbiol Biotechnol, 2008 Sep. PMID 18597084

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetate ester metabolic process involved in fermentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in acetate ester metabolic process involved in fermentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alcohol O-acetyltransferase
    NP_015022.3
    • Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1046226..1047803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183797.3 → NP_015022.3  TPA: alcohol O-acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015022.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W370, P40353, Q08901
      UniProtKB/TrEMBL
      A0A5J6SG86, A0A5J6SGW0, A0A5J6SGW7, A0A5J6SKC0, A6ZPK5, B3LK31, B5VSQ1, C7GVG9, C8ZHC6, N1NWA4
      Conserved Domains (1) summary
      pfam07247
      Location:28 → 522
      AATase; Alcohol acetyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40353.2

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