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    PBI2 Pbi2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855717, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PBI2
    Official Full Name
    Pbi2p
    Primary source
    SGD:S000004960
    Locus tag
    YNL015W
    See related
    AllianceGenome:SGD:S000004960; FungiDB:YNL015W; VEuPathDB:YNL015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LMA1
    Summary
    Enables endopeptidase inhibitor activity. Involved in regulation of proteolysis and vacuole fusion, non-autophagic. Located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PBI2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (605384..605611)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene Pub1p Neighboring gene translation elongation factor EF-3 Neighboring gene putative carboxylic ester hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural occurrence and chemical modification of proteinase B inhibitors from yeast. Bünning P, et al. J Biol Chem, 1977 Aug 10. PMID 328499
    2. Purification and molecular characterization of two inhibitors of yeast proteinase B. Maier K, et al. J Biol Chem, 1979 Sep 10. PMID 381308
    3. Levels and turnover of the proteinase B inhibitors in yeast. Betz H. Biochim Biophys Acta, 1975 Sep 8. PMID 1100120
    4. Involvement of the C-terminal region of yeast proteinase B inhibitor 2 in its inhibitory action. Kojima S, et al. J Mol Biol, 1999 Feb 26. PMID 10024450
    5. The proteinase yscB inhibitor (PB12) gene of yeast and studies on the function of its protein product. Schu P, et al. Eur J Biochem, 1991 Apr 10. PMID 2015812

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Pbi2p
    NP_014383.1
    • Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      605384..605611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182854.1 → NP_014383.1  TPA: Pbi2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1G3, P01095, P0CT04, P0CT05
      UniProtKB/TrEMBL
      A6ZS62, B3LPQ0, C7GJF3, C8ZFL2, G2WL43, N1NWQ7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CT04.1

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