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    FDH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854570, updated on 22-Aug-2024

    Summary

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    Official Symbol
    FDH1
    Primary source
    FungiDB:YOR388C
    Locus tag
    YOR388C
    See related
    SGD:S000005915; AllianceGenome:SGD:S000005915; VEuPathDB:YOR388C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables formate dehydrogenase (NAD+) activity. Involved in formate catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1071793..1072923, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene deoxyribodipyrimidine photo-lyase PHR1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene fluoride transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering of coenzyme specificity of formate dehydrogenase from Saccharomyces cerevisiae. Serov AE, et al. Biochem J, 2002 Nov 1. PMID 12144528, Free PMC Article
    2. Regulation and evaluation of five methanol-inducible promoters in the methylotrophic yeast Candida boidinii. Yurimoto H, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978507
    3. Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae. Overkamp KM, et al. Yeast, 2002 Apr. PMID 11921099
    4. Systems-level engineering of nonfermentative metabolism in yeast. Kennedy CJ, et al. Genetics, 2009 Sep. PMID 19564482, Free PMC Article
    5. Efficient fermentation of xylose to ethanol at high formic acid concentrations by metabolically engineered Saccharomyces cerevisiae. Hasunuma T, et al. Appl Microbiol Biotechnol, 2011 May. PMID 21246355

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables formate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables formate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formate catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formate dehydrogenase (NAD+)
    NP_015033.1
    • NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1071793..1072923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183808.1 → NP_015033.1  TPA: formate dehydrogenase (NAD+) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZN46, C8ZHD6, D6W381, N1P3Y5, P0CT22, Q08911
      UniProtKB/TrEMBL
      G2WNP8
      Conserved Domains (1) summary
      cd05302
      Location:4 → 371
      FDH; NAD-dependent Formate Dehydrogenase (FDH)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08911.1

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