FEX1 fluoride transporter [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FEX1
Official Full Name: fluoride transporter
Primary source: SGD:S000005917
Locus tag: YOR390W
See related: AllianceGenome:SGD:S000005917; FungiDB:YOR390W; VEuPathDB:YOR390W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables fluoride transmembrane transporter activity. Involved in fluoride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Engineered fluoride sensitivity enables biocontainment and selection of genetically-modified yeasts.
Title: Engineered fluoride sensitivity enables biocontainment and selection of genetically-modified yeasts.
FEX1 is a constitutively expressed fluoride channel, and mutations to the C- and N-terminal domains have asymmetric effects.
Title: Yeast Fex1p Is a Constitutively Expressed Fluoride Channel with Functional Asymmetry of Its Two Homologous Domains.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables fluoride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fluoride transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables fluoride transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fluoride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fluoride transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fluoride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_015035.1

Protein involved in fluoride export; nearly identical to FEX2, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins

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The following sections contain reference sequences that belong to a specific genome build. Explain