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    CLC1 Clc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853077, updated on 17-May-2024

    Summary

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    Gene symbol
    CLC1
    Gene description
    Clc1p
    Primary source
    FungiDB:YGR167W
    Locus tag
    YGR167W
    See related
    SGD:S000003399; AllianceGenome:SGD:S000003399; VEuPathDB:YGR167W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCD4
    Summary
    Predicted to enable clathrin heavy chain binding activity. Involved in endocytosis; positive regulation of endocytosis; and protein-containing complex assembly. Located in trans-Golgi network. Orthologous to human CLTA (clathrin light chain A) and CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CLC1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (832456..833157)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRPS35 Neighboring gene Trs65p Neighboring gene Pex35p Neighboring gene pseudouridine synthase PUS6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast clathrin has a distinctive light chain that is important for cell growth. Silveira LA, et al. J Cell Biol, 1990 Oct. PMID 2211819, Free PMC Article
    2. Creating a chimeric clathrin heavy chain that functions independently of yeast clathrin light chain. Boettner DR, et al. Traffic, 2016 Jul. PMID 27062026, Free PMC Article
    3. A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae. Chu DS, et al. Mol Biol Cell, 1999 Mar. PMID 10069813, Free PMC Article
    4. A novel structural model for regulation of clathrin function. Pishvaee B, et al. EMBO J, 1997 May 1. PMID 9171338, Free PMC Article
    5. Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast. Huang KM, et al. J Cell Sci, 1997 Apr. PMID 9133677

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLC directs endocytic progression by pruning the Sla2-actin attachments in the clathrin lattice, providing direction for membrane internalization.
      Title: Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin.
    2. We propose that LC binding to Sla2p positively regulates Sla2p for efficient endocytic vesicle formation.
      Title: Novel function of clathrin light chain in promoting endocytic vesicle formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin vesicle coat TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Clc1p
    NP_011683.3
    • Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      832456..833157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181296.3 → NP_011683.3  TPA: Clc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011683.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV0, P17891
      UniProtKB/TrEMBL
      A0A8H4C1W1, A6ZUH7, B3LI64, B5VJB1, C7GQ74, N1P3U4
      Conserved Domains (1) summary
      pfam01086
      Location:1 → 227
      Clathrin_lg_ch; Clathrin light chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17891.1

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