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    PDIK1L PDLIM1 interacting kinase 1 like [ Homo sapiens (human) ]

    Gene ID: 149420, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PDIK1Lprovided by HGNC
    Official Full Name
    PDLIM1 interacting kinase 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:18981
    See related
    Ensembl:ENSG00000175087 MIM:610785; AllianceGenome:HGNC:18981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLIK1L; STK35L2
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.2), bone marrow (RPKM 4.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDIK1L in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26111162..26125555)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25948595..25962987)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26437653..26452046)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376910 Neighboring gene Sharpr-MPRA regulatory region 4919 Neighboring gene tripartite motif containing 63 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26405707-26405883 Neighboring gene VISTA enhancer hs2271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 473 Neighboring gene Sharpr-MPRA regulatory region 12487 Neighboring gene Sharpr-MPRA regulatory region 4586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26480925-26481654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26481655-26482384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26482385-26483114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26483115-26483844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26490758-26491327 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26494780-26494935 Neighboring gene family with sequence similarity 110 member D Neighboring gene chromosome 1 open reading frame 230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel human kinase gene, PDIK1L. Guo L, et al. J Genet, 2003 Apr-Aug. PMID 14631099
    2. Phosphorylation of the 26 kDa TNF precursor in monocytic cells and in transfected HeLa cells. Pócsik E, et al. J Inflamm, 1995. PMID 8597870
    3. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Polyanskaya SA, et al. Cell Rep, 2022 Jan 11. PMID 35021089, Free PMC Article
    4. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140, Free PMC Article
    5. Human ORFeome version 1.1: a platform for reverse proteomics. Rual JF, et al. Genome Res, 2004 Oct. PMID 15489335, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
      Title: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PDIK1L
    Names
    casein kinase
    NP_001230461.1
    NP_001230462.1
    NP_690048.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243532.2 → NP_001230461.1  serine/threonine-protein kinase PDIK1L

      See identical proteins and their annotated locations for NP_001230461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL391650, AL834290, BU742621, CV024336, DA221039, DB233669
      Consensus CDS
      CCDS274.1
      UniProtKB/Swiss-Prot
      B2R777, D3DPK2, Q5T2I0, Q8N165, Q8NDB3
      Related
      ENSP00000480635.1, ENST00000619836.4
      Conserved Domains (1) summary
      cd13977
      Location:7 → 331
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    2. NM_001243533.2 → NP_001230462.1  serine/threonine-protein kinase PDIK1L

      See identical proteins and their annotated locations for NP_001230462.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AF411102, AL391650, BU742621, DB227864
      Consensus CDS
      CCDS274.1
      UniProtKB/Swiss-Prot
      B2R777, D3DPK2, Q5T2I0, Q8N165, Q8NDB3
      Related
      ENSP00000363389.4, ENST00000374271.8
      Conserved Domains (1) summary
      cd13977
      Location:7 → 331
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    3. NM_152835.5 → NP_690048.1  serine/threonine-protein kinase PDIK1L

      See identical proteins and their annotated locations for NP_690048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK312872, AL391650, AL834290, BU742621
      Consensus CDS
      CCDS274.1
      UniProtKB/Swiss-Prot
      B2R777, D3DPK2, Q5T2I0, Q8N165, Q8NDB3
      Related
      ENSP00000363387.1, ENST00000374269.2
      Conserved Domains (1) summary
      cd13977
      Location:7 → 331
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      26111162..26125555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      25948595..25962987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N165.1 GenPept UniProtKB/Swiss-Prot:Q8N165

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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