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    VID30 glucose-induced degradation complex subunit VID30 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852624, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VID30
    Official Full Name
    glucose-induced degradation complex subunit VID30
    Primary source
    SGD:S000003196
    Locus tag
    YGL227W
    See related
    AllianceGenome:SGD:S000003196; FungiDB:YGL227W; VEuPathDB:YGL227W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GID1
    Summary
    Involved in negative regulation of gluconeogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of nitrogen utilization. Located in cytoplasm and nucleus. Part of GID complex. Orthologous to human RANBP10 (RAN binding protein 10) and RANBP9 (RAN binding protein 9). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VID30 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (69671..72547)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sap4p Neighboring gene She10p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit Neighboring gene Mtc3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism. Eder M, et al. Sci Rep, 2020 Feb 7. PMID 32034164, Free PMC Article
    2. Vid30 is required for the association of Vid vesicles and actin patches in the vacuole import and degradation pathway. Alibhoy AA, et al. Autophagy, 2012 Jan. PMID 22082961, Free PMC Article
    3. Proteins of newly isolated mutants and the amino-terminal proline are essential for ubiquitin-proteasome-catalyzed catabolite degradation of fructose-1,6-bisphosphatase of Saccharomyces cerevisiae. Hämmerle M, et al. J Biol Chem, 1998 Sep 25. PMID 9737955
    4. Isolation of degradation-deficient mutants defective in the targeting of fructose-1,6-bisphosphatase into the vacuole for degradation in Saccharomyces cerevisiae. Hoffman M, et al. Genetics, 1996 Aug. PMID 8844145, Free PMC Article
    5. The Shape of Vesicle-Containing Organelles Is Critical for Their Functions in Vesicle Endocytosis. Winters CM, et al. DNA Cell Biol, 2017 Nov. PMID 29040005

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
      Title: QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
    2. turnover of both Hxt3 and Hxt7 is dependent on the essential E3 ubiquitin ligase, Rsp5, indicating that the role of the Vid30c might be indirect of Hxt ubiquitylation
      Title: Regulation of Hxt3 and Hxt7 turnover converges on the Vid30 complex and requires inactivation of the Ras/cAMP/PKA pathway in Saccharomyces cerevisiae.
    3. Three members of the VID and GID gene families, VID30/GID1, GID2, and VID28/GID5 are needed for the rapamycin or nitrogen starvation-induced degradation of the high-affinity hexose transporter Hxt7p is shown here.
      Title: Components of the Vid30c are needed for the rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-induced degradation complex subunit VID30
    NP_011287.1
    • Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      69671..72547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181093.1 → NP_011287.1  TPA: glucose-induced degradation complex subunit VID30 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011287.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVA7, P53076
      UniProtKB/TrEMBL
      A6ZTW3, B3LHS0, B5VIB4, C7GNX4
      Conserved Domains (3) summary
      smart00668
      Location:769 → 826
      CTLH; C-terminal to LisH motif
      smart00757
      Location:828 → 935
      CRA; CT11-RanBPM
      cd12885
      Location:386 → 588
      SPRY_RanBP_like; SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53076.1

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