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    VMA1 H(+)-transporting V1 sector ATPase subunit A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851342, updated on 28-Oct-2024

    Summary

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    Official Symbol
    VMA1
    Official Full Name
    H(+)-transporting V1 sector ATPase subunit A
    Primary source
    SGD:S000002344
    Locus tag
    YDL185W
    See related
    AllianceGenome:SGD:S000002344; FungiDB:YDL185W; VEuPathDB:YDL185W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CLS8; TFP1
    Summary
    Enables proton-transporting ATPase activity, rotational mechanism. Involved in vacuolar acidification. Located in fungal-type vacuole membrane. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See VMA1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (126787..130002)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphoprotein phosphatase 2A catalytic subunit PPH22 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L41A Neighboring gene Mrx19p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Photoaffinity labeling of wild-type and mutant forms of the yeast V-ATPase A subunit by 2-azido-[(32)P]ADP. MacLeod KJ, et al. J Biol Chem, 1999 Nov 12. PMID 10551850
    2. Substrate recognition and induced DNA distortion by the PI-SceI endonuclease, an enzyme generated by protein splicing. Gimble FS, et al. J Mol Biol, 1996 Oct 25. PMID 8913299
    3. Binding, bending and cleavage of DNA substrates by the homing endonuclease Pl-SceI. Wende W, et al. Nucleic Acids Res, 1996 Nov 1. PMID 8932361, Free PMC Article
    4. Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Duan X, et al. Cell, 1997 May 16. PMID 9160747
    5. Probing novel elements for protein splicing in the yeast Vma1 protozyme: a study of replacement mutagenesis and intragenic suppression. Nogami S, et al. Genetics, 1997 Sep. PMID 9286669, Free PMC Article

    See all (215) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of function of the vacuolar H-ATPase (vma1) or a defect in the biosynthesis of the osmolyte glycerol (gpd1) caused a prolonged repression of housekeeping genes and a delay in gene activation and adaptation towards salt stress.
      Title: Coordinated gene regulation in the initial phase of salt stress adaptation.
    2. recruitment of Dmc1p and Rad51p to the TFP1-induced double-strand break repair site
      Title: Recruitment of RecA homologs Dmc1p and Rad51p to the double-strand break repair site initiated by meiosis-specific endonuclease VDE (PI-SceI).
    3. Study suggests that nucleosome positioning or occupancy around the VDE recognition site by itself is not the sole mechanism for the regulation of meiosis-specific DNA cleavage by VDE and that other mechanisms are involved in the regulation.
      Title: Investigation of the mechanism of meiotic DNA cleavage by VMA1-derived endonuclease uncovers a meiotic alteration in chromatin structure around the target site.
    4. the nonhomologous region of subunit A of the yeast V-ATPase is involved in coupling and in vivo dissociation
      Title: Involvement of the nonhomologous region of subunit A of the yeast V-ATPase in coupling and in vivo dissociation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intein-mediated protein splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intron homing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H(+)-transporting V1 sector ATPase subunit A
    NP_010096.1
    • Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      126787..130002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180245.1 → NP_010096.1  TPA: H(+)-transporting V1 sector ATPase subunit A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRG7, O74301, P17255, Q9Y7W5
      UniProtKB/TrEMBL
      C8Z6B9, G2WBY0, N1P711
      Conserved Domains (2) summary
      TIGR01042
      Location:733 → 1063
      V-ATPase_V1_A; V-type (H+)-ATPase V1, A subunit
      pfam05203
      Location:284 → 736
      Hom_end_hint; Hom_end-associated Hint
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17255.3

    Gene LinkOut

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