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    TRE2 putative zinc metalloprotease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854430, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRE2
    Official Full Name
    putative zinc metalloprotease
    Primary source
    SGD:S000005782
    Locus tag
    YOR256C
    See related
    AllianceGenome:SGD:S000005782; FungiDB:YOR256C; VEuPathDB:YOR256C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable carboxypeptidase activity. Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in breast carcinoma; hemochromatosis (multiple); immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to several human genes including NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TRE2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (808254..810683, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene protein-transporting protein SEC63 Neighboring gene Osw1p Neighboring gene centrin Neighboring gene DNA 5'-adenosine monophosphate hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compensation for the absence of the catalytically active half of DNA polymerase ε in yeast by positively selected mutations in CDC28. Stepchenkova EI, et al. Genetics, 2021 Jun 24. PMID 33844024, Free PMC Article
    2. Transferrin receptor-like proteins control the degradation of a yeast metal transporter. Stimpson HE, et al. EMBO J, 2006 Feb 22. PMID 16456538, Free PMC Article
    3. Sequencing analysis of a 36.8 kb fragment of yeast chromosome XV reveals 26 open reading frames including SEC63, CDC31, SUG2, GCD1, RBL2, PNT1, PAC1 and VPH1. Poirey R, et al. Yeast, 1997 Apr. PMID 9153759
    4. Diversification at transcription factor binding sites within a species and the implications for environmental adaptation. Ames RM, et al. Mol Biol Evol, 2011 Dec. PMID 21693437
    5. Down-regulation of a manganese transporter in the face of metal toxicity. Jensen LT, et al. Mol Biol Cell, 2009 Jun. PMID 19369420, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative zinc metalloprotease
    NP_014899.1
    • Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitination and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      808254..810683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183675.2 → NP_014899.1  TPA: putative zinc metalloprotease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014899.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2V7, Q08693
      UniProtKB/TrEMBL
      B3LJS4, N1P3K5
      Conserved Domains (3) summary
      cd00538
      Location:249 → 392
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      cd03874
      Location:417 → 643
      M28_PMSA_TfR_like; M28 Zn-peptidase Transferrin Receptor-like family
      pfam04253
      Location:668 → 799
      TFR_dimer; Transferrin receptor-like dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08693.1

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