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    FMP30 N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856001, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FMP30
    Official Full Name
    N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D
    Primary source
    SGD:S000006024
    Locus tag
    YPL103C
    See related
    AllianceGenome:SGD:S000006024; FungiDB:YPL103C; VEuPathDB:YPL103C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in N-acylethanolamine metabolic process and N-acylphosphatidylethanolamine metabolic process. Located in mitochondrial inner membrane. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FMP30 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (358000..359406, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Syh1p Neighboring gene aspartate--tRNA ligase MSD1 Neighboring gene Elongator subunit ELP4 Neighboring gene Atg21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Presence and potential signaling function of N-acylethanolamines and their phospholipid precursors in the yeast Saccharomyces cerevisiae. Merkel O, et al. Biochim Biophys Acta, 2005 Jun 1. PMID 15878693
    2. Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Klecker T, et al. Sci Rep, 2015 Dec 16. PMID 26669658, Free PMC Article
    3. Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae. Miyata N, et al. Sci Rep, 2017 Nov 27. PMID 29180659, Free PMC Article
    4. Evolutionary origins of the endocannabinoid system. McPartland JM, et al. Gene, 2006 Mar 29. PMID 16434153
    5. FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis. Kuroda T, et al. Mol Microbiol, 2011 Apr. PMID 21306442

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicated that Fmp30p is involved in the maintenance of mitochondrial morphology and required for the accumulation of a normal level of CL in the absence of mitochondrial phosphatidylethanolamine synthesis.
      Title: FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylethanolamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in N-acylphosphatidylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acylphosphatidylethanolamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D
    NP_015222.1
    • Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      358000..359406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183917.1 → NP_015222.1  TPA: N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3R4, Q02883
      UniProtKB/TrEMBL
      A6ZWE8, B3LKX0, B5VT60, C7GJ57, C8ZIS7, G2WP78, N1P1K6
      Conserved Domains (1) summary
      cl23716
      Location:210 → 397
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02883.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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