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    Y' element ATP-dependent helicase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854906, updated on 2-Nov-2024

    Summary

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    Official Full Name
    Y' element ATP-dependent helicase
    Primary source
    SGD:S000004602
    Locus tag
    YML133C
    See related
    AllianceGenome:SGD:S000004602; FungiDB:YML133C; VEuPathDB:YML133C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable helicase activity. Predicted to be involved in telomere maintenance via recombination. Located in mitochondrion. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human DHX58 (DExH-box helicase 58); RIGI (RNA sensor RIG-I); and IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (461..4684, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cos3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
    2. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article
    3. Analysis of the TORC1 interactome reveals a spatially distinct function of TORC1 in mRNP complexes. Chang Y, et al. J Cell Biol, 2021 Apr 5. PMID 33566094, Free PMC Article
    4. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Ranjitkar P, et al. Mol Cell, 2010 Nov 12. PMID 21070971, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Bowman S, et al. Nature, 1997 May 29. PMID 9169872

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in telomere maintenance via recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Y' element ATP-dependent helicase
    NP_013573.1
    • Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      461..4684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182496.1 → NP_013573.1  TPA: Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013573.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXU4, D6W0F2, Q03099, Q12054, Q99208
      Conserved Domains (1) summary
      COG0513
      Location:314 → 830
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03099.1

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