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    ESC1 Esc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855259, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ESC1
    Official Full Name
    Esc1p
    Primary source
    SGD:S000004832
    Locus tag
    YMR219W
    See related
    AllianceGenome:SGD:S000004832; FungiDB:YMR219W; VEuPathDB:YMR219W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in subtelomeric heterochromatin formation and telomere tethering at nuclear periphery. Located in chromosome, telomeric region and nuclear periphery. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ESC1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (707133..712109)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene GMP synthase (glutamine-hydrolyzing) Neighboring gene transport protein particle complex II subunit TRS130 Neighboring gene phosphomevalonate kinase Neighboring gene Fmp42p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immobility, inheritance and plasticity of shape of the yeast nucleus. Hattier T, et al. BMC Cell Biol, 2007 Nov 9. PMID 17996101, Free PMC Article
    2. The functional importance of telomere clustering: global changes in gene expression result from SIR factor dispersion. Taddei A, et al. Genome Res, 2009 Apr. PMID 19179643, Free PMC Article
    3. Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. Taddei A, et al. EMBO J, 2004 Mar 24. PMID 15014445, Free PMC Article
    4. Elevated dosage of Ulp1 disrupts telomeric silencing in Saccharomyces cerevisiae. Abraham NM, et al. Mol Biol Rep, 2018 Dec. PMID 30357586
    5. Discovery and Evolution of New Domains in Yeast Heterochromatin Factor Sir4 and Its Partner Esc1. Faure G, et al. Genome Biol Evol, 2019 Feb 1. PMID 30668669, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Esc1-interacting region of Sir4 is Dbf4-related H-BRCT domain
      Title: Discovery and Evolution of New Domains in Yeast Heterochromatin Factor Sir4 and Its Partner Esc1.
    2. Data show that Esc1 and Ulp1 help retain unspliced pre-mRNAs in the nucleus, and are essential for proper nuclear basket function, which includes mRNA surveillance and regulation of SUMO protein dynamics.
      Title: A nuclear envelope protein linking nuclear pore basket assembly, SUMO protease regulation, and mRNA surveillance.
    3. Ku- and Esc1-dependent pathways mediate natural telomere anchoring in vivo
      Title: Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere tethering at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Esc1p
    NP_013946.1
    • Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      707133..712109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182726.1 → NP_013946.1  TPA: Esc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W044, Q03661, Q04988
      UniProtKB/TrEMBL
      B3LMA7
      Conserved Domains (2) summary
      COG5271
      Location:945 → 1502
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      TIGR00927
      Location:175 → 442
      2A1904; K+-dependent Na+/Ca+ exchanger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03661.1

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