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    ALA1 alanine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854513, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ALA1
    Official Full Name
    alanine--tRNA ligase
    Primary source
    SGD:S000005862
    Locus tag
    YOR335C
    See related
    AllianceGenome:SGD:S000005862; FungiDB:YOR335C; VEuPathDB:YOR335C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC64
    Summary
    Enables alanine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in alanyl-tRNA aminoacylation. Located in mitochondrion. Used to study Charcot-Marie-Tooth disease; axonal neuropathy; cerebellar ataxia; dermatomyositis; and microcephaly. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N; combined oxidative phosphorylation deficiency 8; developmental and epileptic encephalopathy 29; leukodystrophy (multiple); and trichothiodystrophy. Orthologous to several human genes including AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ALA1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (946233..949109, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit E Neighboring gene Mrs2p Neighboring gene Kre5p Neighboring gene Tea1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae. Wrobel C, et al. J Bacteriol, 1999 Dec. PMID 10601222, Free PMC Article
    2. Translation of a yeast mitochondrial tRNA synthetase initiated at redundant non-AUG codons. Tang HL, et al. J Biol Chem, 2004 Nov 26. PMID 15358761
    3. An unusual pattern of protein expression and localization of yeast alanyl-tRNA synthetase isoforms. Huang HY, et al. Mol Microbiol, 2006 Apr. PMID 16556230
    4. Cross-species and cross-compartmental aminoacylation of isoaccepting tRNAs by a class II tRNA synthetase. Huang HY, et al. J Biol Chem, 2006 Oct 20. PMID 16928688
    5. Impact of alanyl-tRNA synthetase editing deficiency in yeast. Zhang H, et al. Nucleic Acids Res, 2021 Sep 27. PMID 34500470, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alanyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alanine--tRNA ligase
    NP_014980.3
    • Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      946233..949109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183755.3 → NP_014980.3  TPA: alanine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014980.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3LJZ4, B5VSL3, C8ZH87, N1NW84
      Conserved Domains (1) summary
      PLN02900
      Location:7 → 946
      PLN02900; alanyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version

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