CYC1 cytochrome c isoform 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CYC1
Official Full Name: cytochrome c isoform 1
Primary source: SGD:S000003809
Locus tag: YJR048W
See related: AllianceGenome:SGD:S000003809; FungiDB:YJR048W; VEuPathDB:YJR048W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cardiolipin binding activity and electron transfer activity. Involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial intermembrane space. Used to study hyperglycemia and thrombocytopenia. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CYC1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (526335..526664)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study highlights the important role of Lys79 for defining functional redox properties of cyt c.
Title: The K79G Mutation Reshapes the Heme Crevice and Alters Redox Properties of Cytochrome c.
Ligand-mediated regulation of protein assembly occurs frequently in different cellular contexts. Auto-regulated assembly, where a ligand acts as its own competitive inhibitor, provides a mechanism for exquisite control of assembly. Here are characterized the interactions of a recently identified model system in which the oligomerization of cytochrome c is controlled by sulfonato-calix[8]arene.
Title: A Thermodynamic Model of Auto-regulated Protein Assembly by a Supramolecular Scaffold.
Data indicate the equirements for the 7th or 8th position of the TATA element in the cytochrome c isoform 1 (CYC1) promoter.
Title: A Random Screen Using a Novel Reporter Assay System Reveals a Set of Sequences That Are Preferred as the TATA or TATA-Like Elements in the CYC1 Promoter of Saccharomyces cerevisiae.
Thermodynamic and dynamic properties of iso-1-cytochrome c covalently bound to a bare gold surface are here investigated by large scale atomistic simulations.
Title: Surface packing determines the redox potential shift of cytochrome c adsorbed on gold.
The three-dimensional NMR solution structure of yeast cyt c Y67H variant with high peroxidase activity.
Title: Structural basis for cytochrome c Y67H mutant to function as a peroxidase.
The current study is consistent with a model for yCc binding to CcP in which yCc binds predominantly near the region defined by crystallographic structure of the 1:1 yCc-CcP complex
Title: Binding of Yeast Cytochrome c to Forty-Four Charge-Reversal Mutants of Yeast Cytochrome c Peroxidase: Isothermal Titration Calorimetry.
Thermodynamic measurements show that the native conformer is more stable than the His81-heme alkaline conformer for A81H iso-1-cytochrome c. DeltaGu degrees (H2O) is approximately 1.9 kcal/mol for formation of the His81-heme alkaline conformer.
Title: Effect of an Ala81His mutation on the Met80 loop dynamics of iso-1-cytochrome c.
1.45-A resolution structure with the Met80 heme ligand swung out of the heme crevice. This conformational change requires adjustments to the main chain of the heme crevice loop and is facilitated by a trimethyllysine 72-to-alanine mutation.
Title: Structure of a mitochondrial cytochrome c conformer competent for peroxidase activity.
Data indicate that Y48H missense mutation of cytochrome c (CYCS) gene is associated with growth and respiratory defects.
Title: Mutations of cytochrome c identified in patients with thrombocytopenia THC4 affect both apoptosis and cellular bioenergetics.
pH-jump kinetic studies of the His79-heme alkaline transition show that both the forward and backward rates of conformational change are increased by the Trimethyllysine 72 to Ala substitution.
Title: Mutation of trimethyllysine 72 to alanine enhances His79-heme-mediated dynamics of iso-1-cytochrome c.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cardiolipin binding	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome c isoform 1

NP_012582.1

Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

526335..526664

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181706.1 → NP_012582.1 TPA: cytochrome c isoform 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012582.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWL9, P00044

UniProtKB/TrEMBL

A6ZQ07, B3LQD7, C7GVF8, C8ZBJ8, G2WH53, N1P029

Conserved Domains (1) summary

COG3474
Location:1 → 109

Cyc7; Cytochrome c2 [Energy production and conversion]