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    Gstt4 glutathione S-transferase, theta 4 [ Mus musculus (house mouse) ]

    Gene ID: 75886, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gstt4provided by MGI
    Official Full Name
    glutathione S-transferase, theta 4provided by MGI
    Primary source
    MGI:MGI:1923136
    See related
    Ensembl:ENSMUSG00000009093 AllianceGenome:MGI:1923136
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930583C14Rik
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Orthologous to human GSTT4 (glutathione S-transferase theta 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 184.8) See more
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    Genomic context

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    Location:
    10 C1; 10 38.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75650777..75658405, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75814943..75822566, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 3 Neighboring gene glutathione S-transferase, theta 1 Neighboring gene STARR-positive B cell enhancer ABC_E9794 Neighboring gene STARR-positive B cell enhancer ABC_E5148 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:75300050-75300233 Neighboring gene glutathione S-transferase, theta 2 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami S, et al. Dev Biol, 2010 Apr 1. PMID 20096683
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase theta-4
    Names
    GST class-theta-4
    NP_083748.3
    XP_006514334.1
    XP_030101205.1
    XP_036011963.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029472.3 → NP_083748.3  glutathione S-transferase theta-4

      See identical proteins and their annotated locations for NP_083748.3

      Status: VALIDATED

      Source sequence(s)
      AC142499, AK016340
      Consensus CDS
      CCDS23933.1
      UniProtKB/Swiss-Prot
      Q9D4P7
      Related
      ENSMUSP00000125604.2, ENSMUST00000160211.2
      Conserved Domains (3) summary
      cd03183
      Location:92 → 216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      COG0625
      Location:3 → 170
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75650777..75658405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245345.1 → XP_030101205.1  glutathione S-transferase theta-4 isoform X3

      Conserved Domains (1) summary
      cd03183
      Location:2 → 126
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

    2. XM_006514271.4 → XP_006514334.1  glutathione S-transferase theta-4 isoform X1

      Conserved Domains (2) summary
      cd03050
      Location:42 → 117
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
      cl02776
      Location:131 → 216
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. XM_036156070.1 → XP_036011963.1  glutathione S-transferase theta-4 isoform X2

      Conserved Domains (1) summary
      cl00388
      Location:42 → 105
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4P7.1 GenPept UniProtKB/Swiss-Prot:Q9D4P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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