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    SCT1 bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852271, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCT1
    Official Full Name
    bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
    Primary source
    SGD:S000000107
    Locus tag
    YBL011W
    See related
    AllianceGenome:SGD:S000000107; FungiDB:YBL011W; VEuPathDB:YBL011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GAT2
    Summary
    Enables glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Involved in phospholipid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SCT1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (203538..205817)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rrn6p Neighboring gene methionyl-tRNA formyltransferase Neighboring gene Laa2p Neighboring gene protein kinase ALK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth. Bratschi MW, et al. Eukaryot Cell, 2009 Aug. PMID 19525420, Free PMC Article
    2. The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae. Zheng Z, et al. J Biol Chem, 2001 Nov 9. PMID 11544256
    3. Isolation and characterization of a SCT1 gene which can suppress a choline-transport mutant of Saccharomyces cerevisiae. Matsushita M, et al. J Biochem, 1995 Feb. PMID 7608137
    4. Regulation of phosphatidic acid biosynthetic enzymes in Saccharomyces cerevisiae. Minskoff SA, et al. J Lipid Res, 1994 Dec. PMID 7897322
    5. Differential partitioning of lipids metabolized by separate yeast glycerol-3-phosphate acyltransferases reveals that phospholipase D generation of phosphatidic acid mediates sensitivity to choline-containing lysolipids and drugs. Zaremberg V, et al. J Biol Chem, 2002 Oct 11. PMID 12167660

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. novel mechanism for the regulation of fatty acid desaturation that is based on competition between Ole1p and the glycerol-3-phosphate acyltransferase Sct1p/Gat2p for the common substrate C16:0-CoA
      Title: The yeast acyltransferase Sct1p regulates fatty acid desaturation by competing with the desaturase Ole1p.
    2. Gat1 and Gat2 localized to both perinuclear and cortical endoplasmic reticula in actively proliferating cells.
      Title: Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycerone-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone-phosphate O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerone-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1
    NP_009542.1
    • Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      203538..205817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178251.1 → NP_009542.1  TPA: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPY8, P32784, Q07062, Q96TV1
      UniProtKB/TrEMBL
      G2W8Z7
      Conserved Domains (2) summary
      cd07992
      Location:56 → 343
      LPLAT_AAK14816-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like
      pfam17158
      Location:441 → 548
      MASE4; Membrane-associated sensor, integral membrane domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32784.3

    Gene LinkOut

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