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    NHP2 snoRNA-binding protein NHP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851319, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NHP2
    Official Full Name
    snoRNA-binding protein NHP2
    Primary source
    SGD:S000002367
    Locus tag
    YDL208W
    See related
    AllianceGenome:SGD:S000002367; FungiDB:YDL208W; VEuPathDB:YDL208W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable box H/ACA snoRNA binding activity. Involved in cleavage involved in rRNA processing; rRNA pseudouridine synthesis; and snRNA pseudouridine synthesis. Located in nucleolus. Part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NHP2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (87512..87982)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Uga4p Neighboring gene Cwc2p Neighboring gene nucleoporin GLE1 Neighboring gene Ycx1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. Kolodrubetz D, et al. Yeast, 1991 Feb. PMID 2063628
    2. Accumulation of H/ACA snoRNPs depends on the integrity of the conserved central domain of the RNA-binding protein Nhp2p. Henras A, et al. Nucleic Acids Res, 2001 Jul 1. PMID 11433018, Free PMC Article
    3. Functional conservation and cell cycle localization of the Nhp2 core component of H + ACA snoRNPs in fission and budding yeasts. Maiorano D, et al. Exp Cell Res, 1999 Oct 10. PMID 10502409
    4. Increasing the Depth of Mass-Spectrometry-Based Structural Analysis of Protein Complexes through the Use of Multiple Cross-Linkers. Ding YH, et al. Anal Chem, 2016 Apr 19. PMID 27010980
    5. The cotranscriptional assembly of snoRNPs controls the biosynthesis of H/ACA snoRNAs in Saccharomyces cerevisiae. Ballarino M, et al. Mol Cell Biol, 2005 Jul. PMID 15964797, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables box H/ACA snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box H/ACA snoRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    snoRNA-binding protein NHP2
    NP_010073.2
    • Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      87512..87982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180268.1 → NP_010073.2  TPA: snoRNA-binding protein NHP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010073.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRE6, P32495
      UniProtKB/TrEMBL
      A6ZXC5, B3LH88, C7GV69, C8Z6R1, G2WBV9, N1P6N3
      Conserved Domains (1) summary
      COG1358
      Location:30 → 143
      Rpl7Ae; Ribosomal protein L7Ae or related RNA K-turn-binding protein [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32495.2

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